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再次主动脉根部手术的早期结果是否受到先前根部手术及再次干预指征的影响?

Are early outcomes of reoperative aortic root surgery impacted by previous root procedure and indication for reintervention?

作者信息

Elgharably Haytham, Jenkins Haley, Cekmecelioglu Davut, Ayyat Kamal S, Awad Ahmed K, Vargo Patrick R, Unai Shinya, Roselli Eric E, Svensson Lars G, Pettersson Gosta B

机构信息

Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, Ohio.

Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio.

出版信息

JTCVS Open. 2025 Feb 15;24:31-46. doi: 10.1016/j.xjon.2025.02.005. eCollection 2025 Apr.

Abstract

OBJECTIVE

Reoperative aortic root surgery after a previous root procedure is technically demanding, which can impact outcomes. Herein, we examined the impact of previous root procedure and operative indication on early outcomes.

METHODS

From January 2010 to December 2022, 632 patients underwent reoperative aortic root surgery after previous root procedure (true redo root) at our institution. Baseline characteristics, operative details, and in-hospital complications were compared between groups on the basis of type of previous root prosthesis and infective endocarditis indication.

RESULTS

In the whole cohort, the operative mortality was 2.2% and estimated survival was 93%, 80%, and 67% at 1, 5, and 10 years, respectively. Operative mortality was similar between previous homograft, Bentall, Freestyle, valve-sparing root reimplantation, and Ross (2%, 4%, 0%, 4%, and 0%, respectively,  = .4). Reoperations after Bentall and valve-sparing root reimplantation (prosthetic grafts) had greater rates of postoperative complications, such as reoperation for bleeding (15% and 8%,  = .01), delayed chest closure (18% and 8%,  = .02), and pacemaker insertion (13% and 12%,  = .03). Although there was no significant difference in operative mortality among patients with endocarditis versus those with other indications (3% vs 1%,  = .08), the postoperative course showed greater rates of reoperation for bleeding (19% vs 5%,  < .01) and prolonged ventilation (38% vs 18%,  < .01).

CONCLUSIONS

At experienced centers, aortic root reoperation (true redo root) can be performed with low operative mortality. Explant of prosthetic graft material and endocarditis are associated with more complicated postoperative course, without significantly increased operative mortality.

摘要

目的

在先前进行过根部手术之后再次进行主动脉根部手术,技术要求很高,这可能会影响手术结果。在此,我们研究了先前的根部手术和手术指征对早期结果的影响。

方法

2010年1月至2022年12月,我们机构有632例患者在先前进行过根部手术(真正的再次根部手术)后接受了再次主动脉根部手术。根据先前根部假体的类型和感染性心内膜炎指征,对各组的基线特征、手术细节和住院并发症进行了比较。

结果

在整个队列中,手术死亡率为2.2%,1年、5年和10年的估计生存率分别为93%、80%和67%。先前同种异体移植物、Bentall手术、Freestyle手术、保留瓣膜根部再植入术和Ross手术的手术死亡率相似(分别为2%、4%、0%、4%和0%,P = 0.4)。Bentall手术和保留瓣膜根部再植入术(人工血管)后的再次手术术后并发症发生率更高,如因出血再次手术(15%和8%,P = 0.01)、延迟关胸(18%和8%,P = 0.02)以及起搏器植入(13%和12%,P = 0.03)。尽管感染性心内膜炎患者与其他指征患者的手术死亡率无显著差异(3%对1%,P = 0.08),但术后过程中因出血再次手术的发生率更高(19%对5%,P < 0.01),通气时间延长的发生率也更高(38%对18%,P < 0.01)。

结论

在经验丰富的中心,主动脉根部再次手术(真正的再次根部手术)可以在较低的手术死亡率下进行。人工血管材料的取出和感染性心内膜炎与更复杂的术后过程相关,但手术死亡率并未显著增加。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76f4/12039431/9a2be06ce4bc/fx1.jpg

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