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特纳综合征中的空间缺陷能否由局灶性中枢神经系统功能障碍或非典型语言侧化来解释?

Can spatial deficits in Turner's syndrome be explained by focal CNS dysfunction or atypical speech lateralization?

作者信息

McGlone J

出版信息

J Clin Exp Neuropsychol. 1985 Aug;7(4):375-94. doi: 10.1080/01688638508401271.

DOI:10.1080/01688638508401271
PMID:4031022
Abstract

The spatial impairments of Turner's Syndrome were examined by administering perceptual, constructional, and nonverbal memory tasks to 11 probands and 22 controls matched for phenotypic sex, age, education, and hand preference. Visual imperception was more pronounced than constructional apraxia. Deficits in attention span were present, but they were not restricted to the visual modality or to nonverbal stimuli. Further neuropsychological tests of focal brain dysfunction and speech lateralization revealed slightly increased somatosensory thresholds of the left palm, attenuated manual asymmetry, and diminished right-visual-field superiority on letter identification. Different measures of spatial ability correlated with the somatosensory scores, the manual scores, and the speech representation scores, but the latter three variables showed no significant interrelationships. It is concluded that a unitary explanation in terms of focal CNS dysfunction or atypical speech representation can not account for the pattern of neuropsychological deficits seen in Turner's Syndrome.

摘要

通过对11名先证者和22名在表型性别、年龄、教育程度和利手方面相匹配的对照者进行知觉、构建和非言语记忆任务测试,研究了特纳综合征的空间损伤情况。视觉感知障碍比构建性失用症更为明显。存在注意力持续时间缺陷,但并不局限于视觉模式或非言语刺激。对局部脑功能障碍和言语侧化的进一步神经心理学测试显示,左手掌的体感阈值略有升高,手部不对称性减弱,在字母识别中右视野优势减弱。不同的空间能力测量指标与体感分数、手部分数和言语表征分数相关,但后三个变量之间没有显著的相互关系。得出的结论是,用局部中枢神经系统功能障碍或非典型言语表征的单一解释无法说明特纳综合征中所见的神经心理学缺陷模式。

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引用本文的文献

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J Neurodev Disord. 2021 Nov 4;13(1):52. doi: 10.1186/s11689-021-09401-1.
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Executive Functions in Children and Adolescents with Turner Syndrome: A Systematic Review and Meta-Analysis.特纳综合征患儿和青少年的执行功能:系统评价和荟萃分析。
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