Lyu Cheng, Li Zhuoran, Xu Chuanyun, Wong Kenneth Kin Lam, Luginbuhl David J, McLaughlin Colleen N, Xie Qijing, Li Tongchao, Li Hongjie, Luo Liqun
Department of Biology, Stanford University, Stanford, CA, USA.
Howard Hughes Medical Institute, Stanford University, Stanford, CA, USA.
Science. 2025 May;388(6746):538-544. doi: 10.1126/science.ads7633. Epub 2025 May 1.
A navigating axon faces complex choices when selecting postsynaptic partners in a three-dimensional (3D) space. In this work, we discovered a principle that can establish the 3D glomerular map of the fly antennal lobe by reducing the higher dimensionality serially to 1D projections. During development, olfactory receptor neuron (ORN) axons first contact their partner projection neuron dendrites on the spherical surface of the antennal lobe, regardless of whether the adult glomeruli lie near the surface or inside. Along this 2D surface, axons of each ORN type take a specific, arc-shaped trajectory that precisely intersects with their partner dendrites. Altering axon trajectories compromises synaptic partner matching. A 3D search is thus reduced to one dimension, simplifying partner matching.
在三维（3D）空间中选择突触后伴侣时，导航轴突面临着复杂的选择。在这项研究中，我们发现了一个原理，通过将高维空间依次降维到一维投影，可以建立果蝇触角叶的3D肾小球图谱。在发育过程中，嗅觉受体神经元（ORN）轴突首先在触角叶的球形表面接触其伴侣投射神经元树突，而不管成年肾小球是位于表面附近还是内部。沿着这个二维表面，每种ORN类型的轴突都采取特定的弧形轨迹，精确地与其伴侣树突相交。改变轴突轨迹会损害突触伴侣匹配。因此，三维搜索被简化为一维，从而简化了伴侣匹配。
