Summers B A, Appel M J
J Comp Pathol. 1985 Jul;95(3):425-35. doi: 10.1016/0021-9975(85)90047-7.
Syncytia formation has been observed in response to experimental Canine Distemper Virus (CDV) infection in specific-pathogen-free Beagle dogs. Multinucleated giant cells are most frequently found in white matter lesions of the brain and in the anterior uvea of the eye. Lymph nodes and the lung are occasionally positive, while the leptomeninges will also rarely harbour syncytia. The mechanism of syncytia formation and their possible importance in the pathogenesis of the disease are briefly discussed. Widespread tissue syncytia formation is a feature of CDV infection which should assist in identifying cases of non-suppurative encephalitis in the dog caused by this agent.
在无特定病原体的比格犬实验性感染犬瘟热病毒（CDV）后，观察到了多核巨细胞形成。多核巨细胞最常见于脑白质病变和眼前葡萄膜。淋巴结和肺偶尔呈阳性，而软脑膜也很少有多核巨细胞。简要讨论了多核巨细胞形成的机制及其在疾病发病机制中的可能重要性。广泛的组织多核巨细胞形成是CDV感染的一个特征，这有助于识别由该病原体引起的犬非化脓性脑炎病例。
