Kofoed M L, Wantzin G L
J Am Acad Dermatol. 1985 Jul;13(1):50-4. doi: 10.1016/s0190-9622(85)70142-9.
In a follow-up study of 140 patients with lichen planus we found fifteen patients with a clinically and/or histologically verified family history of the disease, which gives a percentage much higher than that found in previous studies. The reason for this discrepancy might be caused by difficulties in the detection of the disease in family members. Familial lichen planus was found to be different from nonfamilial lichen planus, especially in its effect on young persons and in being a more widespread type with a tendency to result in relapse. The high incidence of familial lichen planus supports the hypothesis that genetic factors are of etiologic importance in lichen planus.
在一项对140例扁平苔藓患者的随访研究中，我们发现15例患者有经临床和/或组织学证实的家族病史，这一比例远高于以往研究中的发现。这种差异的原因可能是家庭成员中疾病检测存在困难。发现家族性扁平苔藓与非家族性扁平苔藓不同，特别是在对年轻人的影响方面，以及它是一种更广泛的类型且有复发倾向。家族性扁平苔藓的高发病率支持了遗传因素在扁平苔藓病因学中具有重要意义这一假说。
