Copeman P W, Tan R S, Timlin D, Samman P D
Br J Dermatol. 1978 May;98(5):573-7. doi: 10.1111/j.1365-2133.1978.tb01945.x.
When lichen planus strikes families, a very rare happening, it is likely to afflict younger members, to erupt more acutely, extensively, and gravely, attacking also nails and mucous membranes, and to recur. Ten patients with familial lichen planus, two each from five distinct Caucasian families, the parents of whom were unrelated by birth, were found to be carrying HLA-B7 statistically more frequently than in the normal population or in those with the characteristic forms of lichen planus. We hint that their genotype might have rendered them susceptible to a pathogen that precipitated their disease.
扁平苔藓在家族中发病是极为罕见的情况，发病时往往累及较年轻的成员，起病更为急剧、广泛且严重，还会侵犯指甲和黏膜，并且容易复发。我们发现，在五个不同的白种人家庭中，每个家庭有两名家族性扁平苔藓患者，其父母均无血缘关系，这些患者携带HLA - B7的比例在统计学上高于正常人群或具有典型扁平苔藓症状的人群。我们推测，他们的基因型可能使他们易受某种病原体侵袭，从而引发疾病。
