Mafe Alice Njolke, Nkene Istifanus Haruna, Ali Ali B M, Edo Great Iruoghene, Akpoghelie Patrick Othuke, Yousif Emad, Isoje Endurance Fegor, Igbuku Ufuoma Augustina, Ismael Shams A, Essaghah Arthur Efeoghene Athan, Ahmed Dina S, Umar Huzaifa, Alamiery Ahmed A
Department of Biological Sciences, Faculty of Science, Taraba State University Jalingo, Taraba State, Jalingo, Nigeria.
Department of Microbiology, Faculty of Natural and Applied Sciences, Nasarawa State University, Keffi, Nigeria.
Probiotics Antimicrob Proteins. 2025 May 2. doi: 10.1007/s12602-025-10569-4.
Mycotoxin contamination poses severe risks to food safety and agricultural sustainability. Probiotic-based interventions offer a promising strategy for mitigating these toxic compounds through adsorption, biodegradation, and gut microbiota modulation. This review examines the mechanisms by which specific probiotic strains inhibit mycotoxin biosynthesis, degrade existing toxins, and enhance host detoxification pathways. Emphasis is placed on strain-specific interactions, genetic and metabolic adaptations, and advancements in formulation technologies that improve probiotic efficacy in food matrices. Also, the review explores smart delivery systems, such as encapsulation techniques and biofilm applications, to enhance probiotic stability and functionality. Issues related to regulatory approval, strain viability, and large-scale implementation are also discussed. By integrating molecular insights, applied case studies, and innovative probiotic-based solutions, this review provides a roadmap for advancing safe and sustainable strategies to combat mycotoxin contamination in food and agricultural systems.
霉菌毒素污染对食品安全和农业可持续性构成严重风险。基于益生菌的干预措施为通过吸附、生物降解和调节肠道微生物群来减轻这些有毒化合物提供了一种有前景的策略。本综述探讨了特定益生菌菌株抑制霉菌毒素生物合成、降解现有毒素以及增强宿主解毒途径的机制。重点关注菌株特异性相互作用、遗传和代谢适应性，以及提高益生菌在食品基质中功效的制剂技术进展。此外，本综述还探讨了智能递送系统，如包囊技术和生物膜应用，以增强益生菌的稳定性和功能。还讨论了与监管批准、菌株活力和大规模实施相关的问题。通过整合分子见解、应用案例研究和基于益生菌的创新解决方案，本综述为推进安全和可持续的策略以对抗食品和农业系统中的霉菌毒素污染提供了路线图。
