Samami Elahe, Baghbanian Seyed Mohammad, Nezhad Seyedeh Zeynab Hossein, Shahhosseini Zohreh, Moosazadeh Mahmood, Elyasi Forouzan
Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran.
Neurology Department, School of Medicine, Booalisina Hospital, Mazandaran University of Medical Sciences, Sari, Iran.
Neuropsychopharmacol Rep. 2025 Jun;45(2):e70022. doi: 10.1002/npr2.70022.
The coronavirus disease 2019 (COVID-19) outbreak raised many concerns along with physical and mental health complications, including adjustment disorder (AD). Given the utmost importance of this issue for vulnerable groups, the present study was to investigate COVID-19-induced AD among Iranian patients living with multiple sclerosis (MS) in 2020.
Adopting a cross-sectional research design, this study was performed on a statistical population of MS patients. Sampling was further done online via Porsline, as a survey tool, in Iran. In total, 247 patients were examined for the period of 2 months, recruiting a sociodemographic-medical information form and the Adjustment Disorder New Module (ADNM). As a final point, the data were analyzed using the SPSS Statistics software (ver. 26).
The MS patients' mean age was 36.10 ± 8.07 years. 82.6% of the participants were female. The AD mean score was also 44.09 ± 13.89, at the moderate level. In this line, a significant relationship was observed between AD among patients with MS and gender (p = 0.001), occupation (p = 0.009), a history of psychiatric disorders (p = 0.001), a history of taking psychiatric medications (p = 0.001), medical appointments canceled due to COVID-19 (p = 0.001), medication shortages amid COVID-19 (p = 0.018), a history of COVID-19 infection (p = 0.018), a history of polymerase chain reaction (PCR) test for COVID-19 (p = 0.042), worry about COVID-19 infection (p = 0.001), fear of familial COVID-19 infection (p = 0.001), and death of friends or relatives caused by COVID-19 (p = 0.025).
The present study established that AD in the MS patients was at the moderate level, and it was even associated with some distinctive variables. So, data from multicenter studies are needed to achieve better recommendations regarding screening psychiatric disorders and supportive strategies in clinical practice.
2019年冠状病毒病（COVID-19）疫情引发了诸多担忧，同时带来了身心健康方面的并发症，包括适应障碍（AD）。鉴于此问题对弱势群体至关重要，本研究旨在调查2020年伊朗多发性硬化症（MS）患者中由COVID-19引发的适应障碍。
本研究采用横断面研究设计，对MS患者的统计总体进行研究。在伊朗，通过在线调查工具Porsline进一步进行抽样。总共对247名患者进行了为期2个月的检查，收集了社会人口统计学-医学信息表和适应障碍新模块（ADNM）。最后，使用SPSS统计软件（版本26）对数据进行分析。
MS患者的平均年龄为36.10±8.07岁。82.6%的参与者为女性。AD平均得分也为44.09±13.89，处于中等水平。在这方面，观察到MS患者中的适应障碍与性别（p = 0.001）、职业（p = 0.009）、精神疾病史（p = 0.001）、服用精神科药物史（p = 0.001）、因COVID-19取消的医疗预约（p = 0.001）、COVID-19期间的药物短缺（p = 0.018）、COVID-19感染史（p = 0.018）、COVID-19聚合酶链反应（PCR）检测史（p = 0.042）、对COVID-19感染的担忧（p = 0.001）、对家庭COVID-19感染的恐惧（p = 0.001）以及COVID-19导致的朋友或亲属死亡（p = 0.025）之间存在显著关系。
本研究确定MS患者中的适应障碍处于中等水平，并且它甚至与一些独特变量相关。因此，需要多中心研究的数据，以便在临床实践中就筛查精神疾病和支持策略获得更好的建议。
