Toshniwal Priya, Mudda Jayashree A, Desai Shrikar, Aniketh R, Jain Sahana
Department of Periodontics and Oral Implantology, HKE's S. N. Institute of Dental Sciences and Research, Kalaburagi, Karnataka, India.
J Indian Soc Periodontol. 2024 Nov-Dec;28(6):664-672. doi: 10.4103/jisp.jisp_209_24. Epub 2025 Apr 3.
Periodontal therapy aims to eliminate the periopathogens involved in disease progression to restore the lost form and function of the tooth-supporting structures. To overcome the drawbacks of conventional treatment, several adjunctive treatment modalities have been successfully used to treat moderate-to-severe periodontal diseases. The present study aims to comparatively evaluate the efficacy of locally delivered tetracycline fibers and antimicrobial photodynamic therapy (PDT) as an adjunct to nonsurgical periodontal treatment, focusing on the possibility of improving the clinical parameters and reducing the microbial load postoperatively.
Twenty-two patients with Stage II Grade B periodontitis were divided into two groups: Group A: scaling and root planing (SRP) + locally delivered tetracycline fibers and Group B: SRP + antimicrobial PDT using indocyanine green as photosensitizer. The following clinical parameters were assessed at baseline, 3 months, and 6 months: Gingival index, modified sulcular bleeding index, clinical attachment level, and probing pocket depth. Subgingival plaque samples were obtained for microbial analysis of , , and at the following periods.
There was significant improvement in clinical and microbiological parameters in both the groups at 3 months and 6 months postoperatively. Microbial recolonization was noted in both the groups, albeit without reaching statistical significance with respect to and at 6 months postoperatively.
From the results obtained, it can be concluded that both local drug delivery and antimicrobial PDT can be used as an effective adjunctive treatment to SRP. However, supportive periodontal care is required to avoid microbial recolonization.
牙周治疗旨在消除参与疾病进展的牙周病原体,以恢复牙齿支持结构丧失的形态和功能。为克服传统治疗的缺点,几种辅助治疗方式已成功用于治疗中重度牙周疾病。本研究旨在比较评估局部应用四环素纤维和抗菌光动力疗法(PDT)作为非手术牙周治疗辅助手段的疗效,重点关注改善临床参数和降低术后微生物负荷的可能性。
22例II B期牙周炎患者分为两组:A组:龈上洁治和根面平整(SRP)+局部应用四环素纤维;B组:SRP+使用吲哚菁绿作为光敏剂的抗菌PDT。在基线、3个月和6个月时评估以下临床参数:牙龈指数、改良龈沟出血指数、临床附着水平和探诊袋深度。在以下时间段获取龈下菌斑样本进行微生物分析。
两组在术后3个月和6个月时临床和微生物学参数均有显著改善。两组均观察到微生物再定植,尽管术后6个月时关于和未达到统计学意义。
从获得的结果可以得出结论,局部药物递送和抗菌PDT均可作为SRP的有效辅助治疗。然而,需要支持性牙周护理以避免微生物再定植。