Spectroscopy Department, Physics Research Institute, National Research Centre, 33 El Behooth St., Dokki, Giza, 60014618, Egypt.
Nonlinear Optical Properties and Fluorescence Spectroscopy Unit, Physics Research Institute, National Research Centre, 33 El Behooth St., Dokki, Giza, 60014618, Egypt.
Lasers Med Sci. 2023 Sep 14;38(1):213. doi: 10.1007/s10103-023-03876-1.
Applications of lasers in phototherapy have been the trend for the last few decades. The photodynamic therapy process normally depends on photosensitizers and laser beams. Through this study, indocyanine green has been used as a photosensitizer, which is normally activated using laser lines between 750 and 805 nm. The activity of the indocyanine green to do fluorescence by other pulsed laser sources has been tested by fluorescence technique, and it has been proven that the laser lines at 810, 940, and 980nm are able to excite the indocyanine green with different extents. The indocyanine green activation has been tested by several laser lines (810, 940, and 980 nm) commonly used as surgical lasers. The generated oxygen has been measured after irradiating the indocyanine green with the different laser lines. A comparison has been made between laser irradiation as a pinpoint and a broad beam. It is found that the wide beam is more effective in activating oxygen production. In the end, it is concluded that lines 810 and 940nm were effective in activating the used dye, while the 980nm activity did not show enough efficiency.
几十年来，激光在光疗中的应用一直是趋势。光动力疗法过程通常依赖于光敏剂和激光束。通过这项研究，已将吲哚菁绿用作光敏剂，通常使用 750 至 805nm 之间的激光线激活。通过荧光技术测试了其他脉冲激光源的吲哚菁绿产生荧光的活性，结果证明 810、940 和 980nm 的激光线能够以不同程度激发吲哚菁绿。已用几种常用作外科激光器的激光线（810、940 和 980nm）测试了吲哚菁绿的激活情况。用不同的激光线辐照吲哚菁绿后测量了生成的氧气。对激光点照射和宽束照射进行了比较。结果表明，宽束照射在激活氧气产生方面更有效。最后得出结论，810nm 和 940nm 激光线有效激活了所用染料，而 980nm 活性则没有显示出足够的效率。
