Zhang Yujia, Iob Eleonora, Tapia Munoz Thamara
Department of Epidemiology and Population Health, University College London (UCL), Gower Street, London, WC1E 6BT, United Kingdom.
Faculty of Nursing, Universidad Andres Bello, Santiago, Chile.
Brain Behav Immun Health. 2025 Apr 21;46:101000. doi: 10.1016/j.bbih.2025.101000. eCollection 2025 Jul.
The study aims to explore the association between anti-inflammatory dietary variables and prevalence of depression and loneliness in older adults.
A cross-sectional secondary data analysis was performed using data from the English Longitudinal Study of Ageing (ELSA), targeting adults aged 50 and over.
Data from wave 9 of ELSA were utilised. Binary logistic regression was employed to estimate the Odds ratios (ORs) and 95 % confidence intervals (CIs) for the association between participants' intake of fruits, vegetables, fish, nuts and seeds, legumes, and wholegrains, and the prevalence of depression and loneliness. Two sets of regressions were conducted: the first set examined each dietary component individually, while the second considered all variables simultaneously. Both models were tested with and without adjusting for covariates, including age, gender, ethnicity, self-rated weight, marital status, education, socio-economic status, and activity-limiting long-standing illnesses.
Of 4254 participants included in the analysis, 355 participants (8 %) had depression, and 623 (15 %) reported experiencing loneliness. An association was observed between higher intakes of fruits and lower prevalence of depression (OR = 0.89, 95 % CI: 0.79-1.00, p = 0.05), and between higher intakes of vegetables and lower prevalence of loneliness (OR = 0.91, 95 % CI: 0.83-1.00, p = 0.05). However, these associations lost statistical significance after adjustment for confounders. Similarly, the second model, which included all anti-inflammatory dietary variables, failed to show a significant association with depression and loneliness.
The study does not support the hypothesis that anti-inflammatory variables are associated with prevalence of depression and loneliness in older adults.
本研究旨在探讨抗炎饮食变量与老年人抑郁症患病率及孤独感之间的关联。
使用英国老龄化纵向研究（ELSA）的数据进行横断面二次数据分析，研究对象为50岁及以上的成年人。
利用ELSA第9轮的数据。采用二元逻辑回归来估计参与者摄入水果、蔬菜、鱼类、坚果和种子、豆类及全谷物与抑郁症患病率及孤独感之间关联的优势比（OR）和95%置信区间（CI）。进行了两组回归分析：第一组分别单独检验每种饮食成分，而第二组同时考虑所有变量。两个模型均在调整协变量前后进行了检验，协变量包括年龄、性别、种族、自我评估体重、婚姻状况、教育程度、社会经济地位以及限制活动的长期疾病。
在纳入分析的4254名参与者中，355名（8%）患有抑郁症，623名（15%）报告有孤独感。观察到水果摄入量较高与抑郁症患病率较低之间存在关联（OR = 0.89，95% CI：0.79 - 1.00，p = 0.05），蔬菜摄入量较高与孤独感患病率较低之间存在关联（OR = 0.91，95% CI：0.83 - 1.00，p = 0.05）。然而，在调整混杂因素后，这些关联失去了统计学意义。同样，包含所有抗炎饮食变量的第二个模型也未显示出与抑郁症和孤独感有显著关联。
本研究不支持抗炎变量与老年人抑郁症患病率及孤独感相关的假设。
