Ye Lingxia, Huang Xin, Xu Yufeng
Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Department of Endocrinology and Metabolism, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui Municipal Central Hospital, Lishui, China.
Front Med (Lausanne). 2025 Apr 17;12:1567128. doi: 10.3389/fmed.2025.1567128. eCollection 2025.
Heart failure (HF) is a major public health concern, and chronic kidney disease (CKD) plays a significant role in its pathogenesis. Understanding the trends and disparities in the burden of HF caused by CKD can provide valuable insights into health policymaking.
This study was a secondary analysis based on previously published data. We obtained global, regional, national, and age- and sex-specific data on the prevalence and years lived with disability (YLDs) of HF caused by CKD from the Global Burden of Disease Study 2021 (GBD 2021) and performed a secondary comparative analysis by age, sex, time, location, sociodemographic index (SDI), and health system level.
In 2021, there were 1,936.9 (95%UI: 1,600.2-2,343.5) thousand cases of HF caused by CKD globally, with an age-standardized rate of YLDs of 3.1 (95%UI: 1.9-4.4) per 100,000 population. The global burden of HF caused by CKD has continuously increased from 1990 to 2021 and is expected to keep growing through 2045 according to predictions. Significant disparities were found across different locations, genders, and ages. Higher burdens were noted among males, older individuals, and regions with lower SDI or less advanced health systems.
The burden of HF caused by CKD has increased significantly since 1990 and varies widely across regions. More significant efforts are needed in the prevention and treatment of CKD and HF, especially among older individuals and males in regions with lower SDI or less advanced health systems.
心力衰竭（HF）是一个重大的公共卫生问题，慢性肾脏病（CKD）在其发病机制中起重要作用。了解由CKD导致的HF负担的趋势和差异可为卫生政策制定提供有价值的见解。
本研究是基于先前发表的数据进行的二次分析。我们从《2021年全球疾病负担研究》（GBD 2021）中获取了关于由CKD导致的HF的患病率和残疾生活年数（YLDs）的全球、区域、国家以及年龄和性别特异性数据，并按年龄、性别、时间、地点、社会人口指数（SDI）和卫生系统水平进行了二次比较分析。
2021年，全球由CKD导致的HF病例有193.69万例（95%不确定区间：160.02万 - 234.35万例），年龄标准化的YLDs率为每10万人3.1例（95%不确定区间：1.9 - 4.4例）。从1990年到2021年，由CKD导致的HF的全球负担持续增加，根据预测，到2045年预计还将继续增长。在不同地点、性别和年龄之间发现了显著差异。男性、老年人以及SDI较低或卫生系统较不发达地区的负担更高。
自1990年以来，由CKD导致的HF负担显著增加，且地区差异很大。在CKD和HF的预防和治疗方面需要做出更大努力，特别是在SDI较低或卫生系统较不发达地区的老年人和男性中。
