对恒河猴（猕猴）进行的针对诺氏疟原虫免疫的长期研究。
Long-term studies on rhesus monkeys (Macaca mulatta) immunized against Plasmodium knowlesi.
作者信息
Cabrera E J, Barr M L, Silverman P H
出版信息
Infect Immun. 1977 Feb;15(2):461-5. doi: 10.1128/iai.15.2.461-465.1977.
Abstract
Studies carried out on four rhesus monkeys (Macaca mulatta) that had been vaccinated against Plasmodium knowlesi show that the immunized animals were protected against a challenge with a heterologous strain of P. knowlesi. This protection was shown to be present even 4 years after the immunization schedule has been completed. The effect could not be attributed toprevious infections with the parasite, since four control rhesus monkeys that had recovered from one to four challenges with P. knowlesi died when exposed to the heterologous strain. Data obtained from the lymphocyte transformation test and the radioimmunoassay are also presented.
摘要
对四只接种了诺氏疟原虫疫苗的恒河猴（猕猴）进行的研究表明，免疫动物对诺氏疟原虫的异源菌株攻击具有抵抗力。即使在完成免疫程序4年后，这种保护作用依然存在。由于四只曾从一到四次诺氏疟原虫攻击中恢复过来的对照恒河猴在接触异源菌株时死亡，所以这种效果不能归因于之前感染过该寄生虫。文中还展示了从淋巴细胞转化试验和放射免疫分析中获得的数据。
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本文引用的文献
1
A NATURALLY ACQUITED QUOTIDIAN-TYPE MALARIA IN MAN TRANSFERABLE TO MONKEYS.
Science. 1965 Aug 20;149(3686):865. doi: 10.1126/science.149.3686.865.
2
Immunity to malaria. I. Protection against Plasmodium knowlesi shown by monkeys sensitized with drug-suppressed infections or by dead parasites in Freund's adjuvant.
Exp Parasitol. 1970 Oct;28(2):304-17. doi: 10.1016/0014-4894(70)90101-3.
3
Immunity to malaria: antigenic variation in chronic infections of Plasmodium knowlesi.
Nature. 1965 Dec 25;208(5017):1286-8. doi: 10.1038/2081286a0.
4
Susceptibility of a new world monkey (Aotus trivirgatus) to an old world simian malarial parasite (Plasmodium knowlesi).
Trans R Soc Trop Med Hyg. 1974;68(5):387-91. doi: 10.1016/0035-9203(74)90154-0.
5
Vaccination of rhesus monkeys against malaria by use of sucrose density gradient fractions of Plasmodium knowlesi antigens.
Nature. 1974 Feb 1;247(5439):304-5. doi: 10.1038/247304a0.
6
Vaccination of Rhesus monkeys (Macaca mulatta) against Plasmodium knowlesi by the use of nonviable antigen.
Bull World Health Organ. 1973 May;48(5):597-604.
7
Merozoite vaccination against Plasmodium knowlesi malaria.
Immunology. 1975 Aug;29(2):397-407.
8
Qualitative analysis of phospholipids isolated from nonviable Plasmodium antigen.
Exp Parasitol. 1975 Apr;37(2):164-72. doi: 10.1016/0014-4894(75)90067-3.
9
Ultrastructural study of Plasmodium knowlesi antigen used in vaccination of rhesus monkeys.
J Protozool. 1976 Aug;23(3):437-42. doi: 10.1111/j.1550-7408.1976.tb03806.x.
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