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用诺氏疟原虫裂殖子疫苗接种诱导的疟疾免疫的抗体介导机制。

Antibody mediated mechanisms of immunity to malaria induced by vaccination with Plasmodium knowlesi merozoites.

作者信息

Butcher G A, Mitchell G H, Cohen S

出版信息

Immunology. 1978 Jan;34(1):77-86.

PMID:414993
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1457343/
Abstract

Rhesus monkeys vaccinated with merozoites in FCA are protected against challenge with several strains and variants of Plasmodium knowlesi. Vaccination induces sterilizing immunity which is species specific. Merozoite-blocking (inhibitory) antibody usually correlates with clinical immunity and protection can be passively transferred with immune sera provided these contain high levels of inhibitory antibody. However, vaccination using adjuvants other than FCA may induce inhibitory antibody without clinical protection. In addition, vaccinated animals may become susceptible to challenge 4-5 weeks after splenectomy, although inhibitory antibody levels are not reduced. These observations indicate that immunity induced by merozoite vaccination involves: (i) merozoite blocking (inhibitory) antibody, (ii) specific antibody or immune complexes acting synergistically with cytotoxic splenic cells stimulated by FCA.

摘要

用弗氏完全佐剂（FCA）中的裂殖子对恒河猴进行疫苗接种后，可使其免受诺氏疟原虫多种菌株和变体的攻击。疫苗接种可诱导产生具有种属特异性的绝育免疫。裂殖子阻断（抑制性）抗体通常与临床免疫相关，并且如果免疫血清中含有高水平的抑制性抗体，保护作用可以通过免疫血清被动转移。然而，使用FCA以外的佐剂进行疫苗接种可能会诱导产生抑制性抗体，但却没有临床保护作用。此外，尽管抑制性抗体水平没有降低，但接种疫苗的动物在脾切除术后4至5周可能会变得易于受到攻击。这些观察结果表明，裂殖子疫苗接种诱导的免疫涉及：（i）裂殖子阻断（抑制性）抗体，（ii）与FCA刺激的细胞毒性脾细胞协同作用的特异性抗体或免疫复合物。

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本文引用的文献

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Antigenic variation and immunity to Plasmodium knowlesi: antibodies which induce antigenic variation and antibodies which destroy parasites.诺氏疟原虫的抗原变异与免疫：诱导抗原变异的抗体和破坏寄生虫的抗体。
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