Yuan Wanjuan, Pei Caixia, Huang Junkai, Chen Hongyu, Fan Juanying, Jin Cheng, Huang Li
Key Laboratory of Microbial Pathogenesis and Interventions of Fujian Province University, the Key Laboratory of Innate Immune Biology of Fujian Province, Biomedical Research Center of South China, College of Life Sciences Fujian Normal University Fuzhou China.
State Key Laboratory of Microbial Resources, Institute of Microbiology Chinese Academy of Sciences Beijing China.
mLife. 2025 Apr 3;4(2):219-222. doi: 10.1002/mlf2.70008. eCollection 2025 Apr.
Spindle-shaped viruses exclusively infect archaea. Fuselloviruses represent a large group of spindle-shaped viruses and infect hyperthermophilic archaea of the order . Although the first fusellovirus was identified nearly 40 years ago, the mechanism of host infection by these viruses remains poorly understood. Here, we show that SSV19, a fusellovirus isolated from a hot spring in the Philippines, is capable of hydrolyzing the host cell surface glycan identified as a heptasaccharide chain of QuiSHexHexNAc. Our findings provide significant insights into the molecular strategy of host recognition and, possibly, entry by an archaeal virus.
纺锤状病毒专门感染古菌。丝状病毒是一大类纺锤状病毒，可感染 目 的嗜热古菌。尽管第一种丝状病毒是在近 40 年前被鉴定出来的，但这些病毒感染宿主的机制仍知之甚少。在这里，我们表明，从菲律宾温泉中分离出的丝状病毒 SSV19 能够水解被鉴定为 QuiSHexHexNAc 七糖链的宿主细胞表面聚糖。我们的发现为古菌病毒识别宿主以及可能进入宿主的分子策略提供了重要见解。
