Zufferey M M, Welti H
J Gynecol Obstet Biol Reprod (Paris). 1985;14(4):523-6.
This study was conducted to assess the efficacy of d-Norgestrel associated with Ethinylestradiol (Neogynon 21) as postcoital contraception and to report on the clinical experience obtained with this type of contraception. 323 women were treated during 72 h. period following unprotected intercourse. All subjects received 0,2 mg Ethinylestradiol and 1 mg d-Norgestrel (Levonorgestrel) in 2 equally divided doses 12 hours apart. - 1 mg Levonorgestrel was observed to be as effective as 2 mg of the racemic Norgestrel. PCC given during the first part of the cycle, shortened the latter in 80% of relevant cases. Nausea occurred in 30.3% of all patients; among these 14.2% also mentioned vomiting. Three pregnancies occurred of which only one could be attributed to method failure. The corrected failure rate is thus estimated at 0.3%.
本研究旨在评估炔诺孕酮与炔雌醇（复方炔诺酮片21片）作为房事后避孕方法的有效性，并报告使用这种避孕方法所获得的临床经验。323名妇女在无保护性交后的72小时内接受了治疗。所有受试者接受0.2毫克炔雌醇和1毫克炔诺孕酮（左炔诺孕酮），分2剂等量服用，间隔12小时。观察到1毫克左炔诺孕酮与2毫克消旋炔诺孕酮的效果相同。在周期的第一阶段给予房事后避孕药，80%的相关病例周期缩短。30.3%的患者出现恶心；其中14.2%的患者还提到呕吐。发生了3例妊娠，其中只有1例可归因于方法失败。因此，校正后的失败率估计为0.3%。
