Lu Grace, Chambers Shae, Cepica Tyler, Xie Lillian, Feng Rui, Werth Victoria P, Chong Benjamin F
Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Department of Dermatology, University of Pennsylvania, Philadelphia, PA, USA.
Br J Dermatol. 2025 Aug 18;193(3):558-560. doi: 10.1093/bjd/ljaf165.
Our study seeks to further characterize the impact of CLASI-A erythema and scale on patient quality of life in a larger multicentre cohort study. We found that both erythema and scale were associated with several PROMs, both at baseline and over time, most notably with patient impressions of disease progression. These findings justify the inclusion of erythema and scale in CLASI-A scoring and has important implications for future treatment directions, as no accepted measure of disease severity currently exists for cutaneous lupus erythematosus.
我们的研究旨在通过一项更大规模的多中心队列研究，进一步明确CLASI-A红斑和鳞屑对患者生活质量的影响。我们发现，无论是在基线时还是随时间推移，红斑和鳞屑均与多项患者报告结局指标（PROMs）相关，最显著的是与患者对疾病进展的感受相关。这些发现证明将红斑和鳞屑纳入CLASI-A评分是合理的，并且对未来的治疗方向具有重要意义，因为目前尚无公认的皮肤红斑狼疮疾病严重程度衡量标准。
