Zhang Ting, Zhou Wenchao, Fan Tingyu, Yuan Yuwei, Tang Xing, Zhang Qunfeng, Zou Juan, Li Yukun
The Second Affiliated Hospital, Department of Gynecology, Hunan Province Key Laboratory of Tumor Cellular & Molecular Pathology, Hengyang Medical School, Cancer Research Institute, University of South China, Hengyang, Hunan, China.
Department of Assisted Reproductive Centre, Zhuzhou Central Hospital, Xiangya Hospital Zhuzhou Central South University, Central South University, Zhuzhou, Hunan, China.
Discov Oncol. 2025 May 2;16(1):657. doi: 10.1007/s12672-025-02364-y.
Lactic acid is significantly expressed in many cancers, including gynecological cancer, and has become a key regulator of the proliferation, development, metastasis and invasion of these cancers. In clinical and experimental studies, the level of lactic acid in gynecological cancer is closely related to metastasis and invasion, tumor recurrence and poor prognosis. Lactic acid can regulate the internal metabolic pathway of gynecological cancer cells and drive the autonomous role of non-cancer cells in gynecological cancer. In addition to being used as a source of energy metabolism by gynecological cancer cells, lactic acid can also be transported from cancer cells to neighboring cancer cells, stroma and vascular endothelial cells (ECs) to further guide metabolic reprogramming. Lactic acid is also involved in promoting inflammation and angiogenesis in gynecologic tumors. Therefore, we reviewed the mechanisms and recent advances in the production and transport of lactic acid in gynecological cancer. These advances and evidence suggest that targeted lactic acid metabolism is a promising cancer treatment.
乳酸在包括妇科癌症在内的许多癌症中均有显著表达，并已成为这些癌症增殖、发展、转移和侵袭的关键调节因子。在临床和实验研究中，妇科癌症中的乳酸水平与转移和侵袭、肿瘤复发及预后不良密切相关。乳酸可调节妇科癌细胞的内部代谢途径，并驱动非癌细胞在妇科癌症中的自主作用。除了作为妇科癌细胞能量代谢的来源外，乳酸还可从癌细胞转运至邻近癌细胞、基质和血管内皮细胞，以进一步引导代谢重编程。乳酸还参与促进妇科肿瘤中的炎症和血管生成。因此，我们综述了妇科癌症中乳酸产生和转运的机制及最新进展。这些进展和证据表明，靶向乳酸代谢是一种很有前景的癌症治疗方法。
