Zhang Wen, Lin Ying-Tong, Jiang Jing-Wen, Hu Yan
Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, Chengdu, China; Department of Ultrasonic Medicine, West China Second University Hospital of Sichuan University, Chengdu, China.
West China School of Medicine, West China Hospital, Sichuan University, Chengdu, China.
Curr Probl Cancer. 2025 Feb;54:101155. doi: 10.1016/j.currproblcancer.2024.101155. Epub 2024 Nov 9.
Gynecological tumors, primarily ovarian cancer (OC), cervical cancer (CC), and endometrial cancer (EC), have a significant global impact on women's health, characterized by high mortality rates. Emerging evidence underscores the pivotal role of altered glucose metabolism in the initiation and progression of these malignancies. Glucose metabolism, encompassing glycolysis, the tricarboxylic acid (TCA) cycle, oxidative phosphorylation, and the pentose phosphate pathway (PPP), among others, is intricately governed by a spectrum of key enzymes. These enzymes drive metabolic reprogramming essential for tumor growth and survival, thereby influencing patient outcomes and clinical management strategies. However, the comprehensive characterization and summary of the expression profiles, regulatory networks involved, and functional roles of these glucose metabolic enzymes in human gynecological tumors remain incomplete. In this review, we systematically map the expression landscape of these critical glucose metabolic enzymes in gynecological cancers based on research utilizing clinical gynecological tumor tissues. Additionally, we summarize the specific functions of key enzymes of glucose metabolism and the pathways they regulate in gynecological tumors. This review provides profound insights into the metabolic dynamics underlying these diseases. This understanding illuminates the metabolic strategies employed by tumor cells and sets the stage for innovative therapeutic approaches targeting cancer cell glucose metabolic dependencies, thereby holding promise for enhancing patient outcomes in gynecological oncology.
妇科肿瘤，主要是卵巢癌（OC）、宫颈癌（CC）和子宫内膜癌（EC），对全球女性健康有重大影响，其特点是死亡率高。新出现的证据强调了糖代谢改变在这些恶性肿瘤发生和发展中的关键作用。糖代谢包括糖酵解、三羧酸（TCA）循环、氧化磷酸化和磷酸戊糖途径（PPP）等，受一系列关键酶的复杂调控。这些酶驱动着对肿瘤生长和存活至关重要的代谢重编程，从而影响患者的预后和临床管理策略。然而，这些糖代谢酶在人类妇科肿瘤中的表达谱、相关调控网络及功能作用的全面表征和总结仍不完整。在本综述中，我们基于对临床妇科肿瘤组织的研究，系统地描绘了这些关键糖代谢酶在妇科癌症中的表达情况。此外，我们总结了糖代谢关键酶的具体功能及其在妇科肿瘤中所调控的途径。本综述为这些疾病潜在的代谢动态提供了深刻见解。这种理解阐明了肿瘤细胞采用的代谢策略，并为针对癌细胞糖代谢依赖性的创新治疗方法奠定了基础，从而有望改善妇科肿瘤患者的预后。
