Patton Declan A, Grunig Ciara S, McQuaid Jessica R, Dodd Andrew B, Pacheco Mandy K, Ling Josef M, Wick Tracey V, Sasi Kumar Divyasree, Zotev Vadim, Kinsler Rachel E, Arbogast Kristy B, Mayer Andrew R
Center for Injury Research and Prevention, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
The Mind Research Network/Lovelace Biomedical Research Institute, Pete & Nancy Domenici Hall, Albuquerque, NM, USA.
Ann Biomed Eng. 2025 May 2. doi: 10.1007/s10439-025-03736-9.
Large mammal head injury models allow the pathophysiological response associated with traumatic brain injury (TBI) to be studied in vivo with precise control of the physical parameters. However, only some studies have used skull-mounted sensors to measure the kinematics of the animal head rather than relying on measurements of the system delivering the impact. Therefore, the aim of the current study was to compare the kinematics between a rotational injury device (HYGE, Inc., Kittanning, PA) and the head in a swine model of TBI across a range of target peak angular velocities.
Sexually mature Yucatan swine were subjected to a rotational TBI via the HYGE device at one of three targeted peak angular velocities: 110 rad/s (n = 16), 145 rad/s (n = 12) or 170 rad/s (n = 11). Sensor packages were used to measure both the angular kinematics of the animal head and HYGE device swing arm.
Peak angular velocity of the animal head was on average 18-33% lower compared to that of the HYGE device swing arm with greater relative differences for greater target peak angular velocities. Similarly, peak angular acceleration of the animal head was lower than that of the HYGE device sing arm by 11-34% on average with greater relative differences for greater target peak angular velocities.
This study highlights the importance of directly measuring the head kinematics of the animal in TBI models for the purpose of directional comparisons, finite element simulations, and/or scaling kinematics from human-to-animal to determine boundary conditions or animal-to-human to develop injury criteria.
大型哺乳动物头部损伤模型能够在体内精确控制物理参数的情况下，研究与创伤性脑损伤（TBI）相关的病理生理反应。然而，只有部分研究使用了安装在颅骨上的传感器来测量动物头部的运动学，而非依赖于对施加撞击的系统进行测量。因此，本研究的目的是在一系列目标峰值角速度下，比较旋转损伤装置（HYGE公司，宾夕法尼亚州基坦宁）与猪TBI模型中头部的运动学。
性成熟的尤卡坦猪通过HYGE装置在三个目标峰值角速度之一接受旋转性TBI：110弧度/秒（n = 16）、145弧度/秒（n = 12）或170弧度/秒（n = 11）。使用传感器套件测量动物头部和HYGE装置摆臂的角运动学。
动物头部的峰值角速度平均比HYGE装置摆臂低18 - 33%，目标峰值角速度越高，相对差异越大。同样，动物头部的峰值角加速度平均比HYGE装置摆臂低11 - 34%，目标峰值角速度越高，相对差异越大。
本研究强调了在TBI模型中直接测量动物头部运动学对于方向比较、有限元模拟和/或从人到动物缩放运动学以确定边界条件或从动物到人类制定损伤标准的重要性。
