Durant Alexis, Sanchez-Migallon Guzman David, Beaufrère Hugues
Am J Vet Res. 2025 May 2;86(8). doi: 10.2460/ajvr.25.03.0076. Print 2025 Aug 1.
To evaluate the thermal antinociceptive effects of hydromorphone hydrochloride administered IM to cockatiels (Nymphicus hollandicus) at higher doses than previously reported.
12 adult cockatiels received hydromorphone IM at doses of 1 and 2 mg/kg and an equivalent volume of saline (0.9% NaCl) solution (control treatment) in a masked, randomized, within-subjects complete crossover study. The thermal foot withdrawal threshold (TFWT) was determined at baseline as well as 0.5, 1.5, 3, and 6 hours postinjection. Agitation-sedation scores were also evaluated at each time point prior to delivery of thermal stimulus. The changes in TFWT compared to baseline as well as agitation-sedation scores prior to each TFWT were compared among treatments over time.
1 bird died during the study for unrelated causes. Hydromorphone at both doses (1 and 2 mg/kg) had a significant difference in foot withdrawal threshold from baseline when compared to the control at the 3-hour postinjection time point. Hydromorphone at 1 mg/kg significantly decreased odds of a bird having higher agitation scores (proportional OR of increase in agitation score of 1, 0.37; 95% CI, 0.14 to 0.96).
Hydromorphone administered IM at doses of 1 and 2 mg/kg had a small but significant thermal antinociceptive effect in cockatiels at 3 hours after drug administration. Hydromorphone at 1 mg/kg demonstrated evidence of mild sedative effects.
This study provides evidence that hydromorphone may provide analgesic effects when administered to cockatiels at doses higher than those evaluated in prior studies. Further studies with other types of noxious stimuli, routes of administration, and testing time points are needed to fully evaluate the analgesic effects of hydromorphone in cockatiels.
以高于先前报道的剂量，评估肌肉注射盐酸氢吗啡酮对鸡尾鹦鹉（虎皮鹦鹉）的热镇痛效果。
在一项采用盲法、随机、受试者内完全交叉研究中，12只成年鸡尾鹦鹉接受了1和2mg/kg剂量的氢吗啡酮肌肉注射，以及等量的生理盐水（0.9%氯化钠）溶液（对照处理）。在基线以及注射后0.5、1.5、3和6小时测定热足退缩阈值（TFWT）。在每次给予热刺激之前的每个时间点，还评估了激动-镇静评分。随着时间推移，比较各处理组与基线相比TFWT的变化以及每次TFWT之前的激动-镇静评分。
1只鸟在研究期间因无关原因死亡。与对照组相比，两种剂量（1和2mg/kg）的氢吗啡酮在注射后3小时时间点，足退缩阈值与基线相比有显著差异。1mg/kg的氢吗啡酮显著降低了鸟类出现较高激动评分的几率（激动评分增加1时的比例优势比为0.37；95%置信区间，0.14至0.96）。
肌肉注射1和2mg/kg剂量的氢吗啡酮在给药后3小时对鸡尾鹦鹉有轻微但显著的热镇痛作用。1mg/kg的氢吗啡酮显示出轻度镇静作用的证据。
本研究提供了证据表明，当以高于先前研究评估的剂量给鸡尾鹦鹉使用氢吗啡酮时，可能会产生镇痛效果。需要进一步开展针对其他类型有害刺激、给药途径和测试时间点的研究，以全面评估氢吗啡酮对鸡尾鹦鹉的镇痛效果。
