Zhang Hui, Jiang Ziyang, Liao Haidang, Li Jiang, Wang Manli, Zhou Yiwu, Hu Zhihong, Liu Jia
State Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China; University of Chinese Academy of Sciences, Beijing, 100049, China.
State Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China.
Virol Sin. 2025 Jun;40(3):499-502. doi: 10.1016/j.virs.2025.04.008. Epub 2025 Apr 30.
• A mouse model for CCHFV-induced coagulopathy was developed and characterized using STAT1 knockout mice. • High doses of CCHFV resulted in delayed tail bleeding time, shortened PT and APTT, and prolonged ELT. • Histopathology showed thrombus formation in the liver and the spleen as well as intestinal hemorrhages.
• 利用STAT1基因敲除小鼠建立并表征了克里米亚-刚果出血热病毒（CCHFV）诱导的凝血病小鼠模型。
• 高剂量的CCHFV导致尾部出血时间延长、凝血酶原时间（PT）和活化部分凝血活酶时间（APTT）缩短，以及优球蛋白溶解时间（ELT）延长。
• 组织病理学显示肝脏、脾脏有血栓形成以及肠道出血。
