Yu Lin, Shi Xiaofeng, Lu Xuanqi, Zhao Xuping, Yu Yaming, Fang Yushan, Wang Deyun
Institute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, PR China.
Institute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, PR China.
Int J Biol Macromol. 2025 Jun;311(Pt 1):143692. doi: 10.1016/j.ijbiomac.2025.143692. Epub 2025 Apr 30.
This study investigated the immunomodulatory effects of Rehmannia glutinosa polysaccharides (RGP) in a cyclophosphamide (CTX)-induced immunosuppression model. RGP treatment alleviated weight loss, immune organ atrophy, and hematological abnormalities, restored B and T cell populations, and enhanced the immune function. It strengthened intestinal barrier integrity by upregulating tight junction proteins, increasing goblet cell numbers, and promoting IgA secretion, while also reducing pro-inflammatory cytokines and increasing IL-10 levels. RGP further regulated the gut microbiota composition, increasing beneficial bacteria and reducing pathogens, while promoting SCFA production and improving metabolic homeostasis. These findings highlight RGP as a potential natural immunomodulator, supporting further research into its molecular mechanisms and clinical applications.
本研究在环磷酰胺（CTX）诱导的免疫抑制模型中，研究了熟地黄多糖（RGP）的免疫调节作用。RGP治疗减轻了体重减轻、免疫器官萎缩和血液学异常，恢复了B细胞和T细胞群体，并增强了免疫功能。它通过上调紧密连接蛋白、增加杯状细胞数量和促进IgA分泌来加强肠道屏障完整性，同时还减少促炎细胞因子并提高IL-10水平。RGP进一步调节肠道微生物群组成，增加有益菌并减少病原菌，同时促进短链脂肪酸的产生并改善代谢稳态。这些发现突出了RGP作为一种潜在的天然免疫调节剂，支持对其分子机制和临床应用的进一步研究。
