来自撒马尔罕阿魏的倍半萜类化合物。
Sesquiterpenoids from Ferula samarkandica.
作者信息
Zhang Miaomiao, Nueraihemaiti Mayire, Kamoldinov Khamidulla, Yan Defeng, Song Yuqing, Xu Nannan, Zou Guoan, Aisa Haji Akber
机构信息
State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization and The Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, People's Republic of China; University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China.
Namangan Engineering-Technological Institute, Namangan, 160115, Uzbekistan.
出版信息
Phytochemistry. 2025 Sep;237:114529. doi: 10.1016/j.phytochem.2025.114529. Epub 2025 Apr 30.
Ten undescribed sesquiterpenes, ferusamarkins A-J, in addition to eight known analogues were isolated from the roots of Ferula samarkandica Korovin native to Uzbekistan. Their structures were established by means of extensive spectroscopic analyses, including HRESIMS, NMR, UV and IR data. The absolute configurations were successfully determined based on ECD calculations in combination with single-crystal X-ray diffraction crystallography. Ferusamarkins A-J exhibit fascinating significance in terms of structural diversity, with sesquiterpene types of eudesmane for ferusamarkins A-E, germacrane for ferusamarkin F, guaiane for ferusamarkins G-I and daucane for ferusamarkin J. The results of bioactivity assays indicated that ferusamarkin E displayed anti-inflammatory property by suppressing the release of NO in LPS-induced Raw264.7 cells, with an IC value of 60.05 ± 5.18 μM.
从乌兹别克斯坦本土的撒马尔罕阿魏（Ferula samarkandica Korovin）的根部分离出了10种未描述的倍半萜类化合物，即撒马尔罕阿魏素A-J，以及8种已知类似物。通过广泛的光谱分析，包括高分辨电喷雾电离质谱（HRESIMS）、核磁共振（NMR）、紫外（UV）和红外（IR）数据确定了它们的结构。结合单晶X射线衍射晶体学通过电子圆二色光谱（ECD）计算成功确定了绝对构型。撒马尔罕阿魏素A-J在结构多样性方面具有迷人的意义，其中撒马尔罕阿魏素A-E为桉叶烷型倍半萜，撒马尔罕阿魏素F为吉马烷型，撒马尔罕阿魏素G-I为愈创木烷型，撒马尔罕阿魏素J为胡萝卜烷型。生物活性测定结果表明，撒马尔罕阿魏素E通过抑制脂多糖（LPS）诱导的Raw264.7细胞中一氧化氮（NO）的释放而具有抗炎特性，半数抑制浓度（IC）值为60.05±5.18μM。
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