萨姆考尔酮倍半萜香豆素类化合物及其生物活性。

Sesquiterpene coumarins from Ferula samarkandica Korovin and their bioactivity.

机构信息

The State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization and Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing South Road 40-1, Urumqi, 830011, China.

S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Prosp. M. Ulugbeka, 83, Tashkent, Uzbekistan.

出版信息

Phytochemistry. 2021 Jul;187:112705. doi: 10.1016/j.phytochem.2021.112705. Epub 2021 May 3.

DOI:10.1016/j.phytochem.2021.112705

PMID:33957541

Abstract

Phytochemical study on the ethanolic extract of the dried roots of Ferula samarkandica Korovin led to the isolation of nine undiscribed sesquiterpene coumarins, samarcandicins A-I, along with thirteen known sesquiterpene coumarins. Their structures were characterized by detailed spectroscopic analysis including NMR and HR-ESI-MS. Mogoltacin and nevskin exhibited high inhibitory activity against MV-4-11 cell with IC values of 3.94 ± 0.06 μM and 3.87 ± 0.10 μM, respectively, and nevskin and feshurin showed high inhibitory activity against mino cell with IC values of 1.48 ± 0.06 μM and 7.88 ± 0.60 μM, respectively.

摘要

对干燥的Ferula samarkandica Korovin 根的乙醇提取物进行植物化学研究，分离得到了 9 种未描述的倍半萜香豆素，即 samarcandicins A-I，以及 13 种已知的倍半萜香豆素。通过详细的光谱分析，包括 NMR 和 HR-ESI-MS，确定了它们的结构。Mogoltacin 和 nevskin 对 MV-4-11 细胞具有很高的抑制活性，IC 值分别为 3.94±0.06 μM 和 3.87±0.10 μM，而 nevskin 和 feshurin 对 mino 细胞具有很高的抑制活性，IC 值分别为 1.48±0.06 μM 和 7.88±0.60 μM。