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Cancers (Basel). 2024 May 8;16(10):1800. doi: 10.3390/cancers16101800.
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Curr Treat Options Oncol. 2023 Mar;24(3):170-183. doi: 10.1007/s11864-023-01050-x. Epub 2023 Jan 31.
4
Efficacy, effectiveness, and safety of herpes zoster vaccine in the immunocompetent and immunocompromised subjects: A systematic review and network meta-analysis.在免疫功能正常和免疫功能低下的受试者中，带状疱疹疫苗的疗效、效果和安全性：系统评价和网络荟萃分析。
Front Immunol. 2022 Sep 30;13:978203. doi: 10.3389/fimmu.2022.978203. eCollection 2022.
5
TCR-engineered T cells targeting E7 for patients with metastatic HPV-associated epithelial cancers.针对转移性 HPV 相关上皮癌患者的 E7 靶向 TCR 工程化 T 细胞。
Nat Med. 2021 Mar;27(3):419-425. doi: 10.1038/s41591-020-01225-1. Epub 2021 Feb 8.
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Pembrolizumab plus GX-188E therapeutic DNA vaccine in patients with HPV-16-positive or HPV-18-positive advanced cervical cancer: interim results of a single-arm, phase 2 trial.帕博利珠单抗联合 GX-188E 治疗性 DNA 疫苗治疗 HPV-16 阳性或 HPV-18 阳性晚期宫颈癌患者：一项单臂、2 期临床试验的中期结果。
Lancet Oncol. 2020 Dec;21(12):1653-1660. doi: 10.1016/S1470-2045(20)30486-1.
7
Immunity to commensal papillomaviruses protects against skin cancer.对共生型乳头瘤病毒的免疫可预防皮肤癌。
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8
An Emerging Issue in Oncogenic Virology: the Role of Beta Human Papillomavirus Types in the Development of Cutaneous Squamous Cell Carcinoma.致癌病毒学中的一个新问题：β型人乳头瘤病毒在皮肤鳞状细胞癌发展中的作用。
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激发人体共生乳头瘤病毒免疫力以对抗癌症。

Inciting commensal human papillomavirus immunity to combat cancer.

作者信息

Fulton Natalie E, Horn Thomas D, Demehri Shadmehr

机构信息

Center for Cancer Immunology, Krantz Family Center for Cancer Research, Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

出版信息

Trends Cancer. 2025 Jul;11(7):616-618. doi: 10.1016/j.trecan.2025.04.006. Epub 2025 May 1.

DOI:10.1016/j.trecan.2025.04.006
PMID:40316467
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12240701/
Abstract

The incidence of squamous cell carcinoma (SCC) is rising, especially in immunosuppressed individuals, highlighting the need for new prevention strategies. Commensal human papillomaviruses (cHPVs) are associated with cutaneous SCC (cSCC) in immunosuppressed patients. Because of the intricate interactions between T cell immunity and cHPVs in virus-colonized tissues, we propose that enhancing T cell immunity against cHPVs through vaccination could suppress SCC.

摘要

鳞状细胞癌（SCC）的发病率正在上升，尤其是在免疫抑制个体中，这凸显了对新预防策略的需求。共生人类乳头瘤病毒（cHPV）与免疫抑制患者的皮肤鳞状细胞癌（cSCC）相关。由于在病毒定植组织中T细胞免疫与cHPV之间存在复杂的相互作用，我们提出通过疫苗接种增强针对cHPV的T细胞免疫可能会抑制SCC。