Jiang Rina, Fritz Mike, Que Syril Keena T
Department of Dermatology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Cancers (Basel). 2024 May 8;16(10):1800. doi: 10.3390/cancers16101800.
Representing the second most common skin cancer, the incidence and disease burden of cutaneous squamous cell carcinoma (cSCC) continues to increase. Surgical excision of the primary site effectively cures the majority of cSCC cases. However, an aggressive subset of cSCC persists with clinicopathological features that are indicative of higher recurrence, metastasis, and mortality risks. Acceleration of these features is driven by a combination of genetic and environmental factors. The past several years have seen remarkable progress in shaping the treatment landscape for advanced cSCC. Risk stratification and clinical management is a top priority. This review provides an overview of the current perspectives on cSCC with a focus on staging, treatment, and maintenance strategies, along with future research directions.
作为第二常见的皮肤癌，皮肤鳞状细胞癌（cSCC）的发病率和疾病负担持续上升。对原发部位进行手术切除可有效治愈大多数cSCC病例。然而，一部分侵袭性cSCC病例具有提示更高复发、转移和死亡风险的临床病理特征。这些特征的加剧是由遗传和环境因素共同驱动的。在过去几年中，晚期cSCC的治疗格局取得了显著进展。风险分层和临床管理是首要任务。本综述概述了目前对cSCC的看法，重点关注分期、治疗和维持策略以及未来的研究方向。
