Jiao Jiao, Yang Haihua, Liang Zhenqi, Pan Yanhui, Yang Jiaxin, Zhang Wenli, Wu Peng
College of Life Sciences, Shihezi University, Shihezi, China.
Ministry of Education Key Laboratory of Xinjiang Phytomedicine Resource Utilization, Shihezi, China.
Sci Rep. 2025 May 2;15(1):15381. doi: 10.1038/s41598-025-99518-3.
Foot-and-mouth disease (FMD) is a highly contagious viral disease of domesticated animals that causes major economic losses globally. In this meta-analysis, 29 studies were evaluated using a random-effects model to analyze the efficacy of FMD vaccines. The quantifying heterogeneity between the groups was low (tau = 0.000, tau = 0.000, and I = 0.0% [0.0%; 24.6%]). The meta-analysis revealed that the inactivated vaccine provides the best protection among different vaccine types, with the following ranking from highest to lowest efficacy: inactivated vaccine > mRNA vaccine > E. coli vaccine > plant vaccine > recombinant virus vaccine > phage vaccine > synthesize vaccine > DNA vaccine > negative control. The findings revealed that the inactivated vaccine provides the best protection among the different types of vaccines. Based on these findings, we recommend using inactivated vaccines as controls in the development of novel vaccines, as they achieved the highest efficacy among all evaluated vaccine types.
口蹄疫（FMD）是一种家养动物的高度传染性病毒性疾病，在全球范围内造成重大经济损失。在这项荟萃分析中，使用随机效应模型评估了29项研究，以分析口蹄疫疫苗的疗效。组间量化异质性较低（tau = 0.000，tau = 0.000，I = 0.0% [0.0%；24.6%]）。荟萃分析显示，在不同类型的疫苗中，灭活疫苗提供了最佳保护，疗效从高到低排序如下：灭活疫苗＞mRNA疫苗＞大肠杆菌疫苗＞植物疫苗＞重组病毒疫苗＞噬菌体疫苗＞合成疫苗＞DNA疫苗＞阴性对照。研究结果表明，灭活疫苗在不同类型的疫苗中提供了最佳保护。基于这些发现，我们建议在新型疫苗的研发中使用灭活疫苗作为对照，因为它们在所有评估的疫苗类型中疗效最高。
