Lafnoune Ayoub, Chbel Asmaa, Darkaoui Bouchra, Wahnou Hicham, Nait Irahal Imane
Laboratoire Santé, Environnement et biotechnologie, Faculté Des Sciences Ain Chock, Université Hassan II de Casablanca, BP5366 Maarif, Casablanca, Morocco.
Laboratoire Immunologie et Biodiversité, Faculté Des Sciences Ain Chock, Université Hassan II de Casablanca, BP5366 Maarif, Casablanca, Morocco.
Arch Toxicol. 2025 May 2. doi: 10.1007/s00204-025-04032-0.
Invertebrate venoms, despite their inherent toxicity, represent a promising source of bioactive compounds with significant anticancer properties. Historically, traditional medicines in Asia, Africa, and other regions have utilized these venoms to treat a variety of diseases, particularly those derived from scorpions, bees, wasps, and cone snails. Contemporary research has illuminated their therapeutic potential, especially in oncology. In vitro and in vivo studies demonstrate that specific toxins from these venoms can inhibit tumor cell proliferation, induce apoptosis, and restrict metastasis. The anticancer efficacy of invertebrate venoms is primarily attributed to their capacity to selectively target malignant cells while minimizing adverse effects on healthy tissues. In addition, bioactive compounds extracted from certain invertebrate venoms exhibit selective cytotoxicity against various cancer cell lines and can inhibit enzymes critical to tumor progression, thereby impeding the invasion and dissemination of cancerous cells. The increasing interest in the application of invertebrate venoms in cancer therapy has spurred further investigations into their therapeutic potential. This review critically evaluates recent scientific advancements concerning the anticancer properties of bioactive molecules derived from invertebrate venoms, elucidating their mechanisms of action and efficacy across different cancer types. We emphasize their potential as viable alternatives or adjuncts to conventional therapies, which are often constrained by their associated toxicity.
尽管无脊椎动物毒液具有内在毒性，但它们是具有显著抗癌特性的生物活性化合物的一个有前景的来源。从历史上看，亚洲、非洲和其他地区的传统医学一直利用这些毒液来治疗各种疾病，特别是那些源自蝎子、蜜蜂、黄蜂和锥螺的毒液。当代研究揭示了它们的治疗潜力，尤其是在肿瘤学方面。体外和体内研究表明，这些毒液中的特定毒素可以抑制肿瘤细胞增殖、诱导细胞凋亡并限制转移。无脊椎动物毒液的抗癌功效主要归因于它们能够选择性地靶向恶性细胞，同时将对健康组织的不良影响降至最低。此外，从某些无脊椎动物毒液中提取的生物活性化合物对各种癌细胞系表现出选择性细胞毒性，并可以抑制对肿瘤进展至关重要的酶，从而阻碍癌细胞的侵袭和扩散。对无脊椎动物毒液在癌症治疗中应用的兴趣日益增加，促使人们对其治疗潜力进行进一步研究。本综述批判性地评估了有关无脊椎动物毒液衍生的生物活性分子抗癌特性的最新科学进展，阐明了它们在不同癌症类型中的作用机制和疗效。我们强调它们作为传统疗法的可行替代方案或辅助手段的潜力，传统疗法往往受到其相关毒性的限制。
