Krahenbuhl B, Bongard O
J Mal Vasc. 1985;10 Suppl A:53-6.
Cutaneous blood flow (Xenon clearance) and transcutaneous pO2 were simultaneously measured on the foot of normal subjects and patients suffering from severe arterial insufficiency of the lower limbs. When the subject is sitting, cutaneous blood flow decreases, as well in normal subjects than in most patients with arterial insufficiency. However, tc pO2 increases in sitting position, probably because local vasoregulation is abolished by local heating. Increase in tc pO2 in sitting position is higher in patients in whom tc pO2 was very low in lying position. In normal subjects, there is a positive correlation between cutaneous blood flow and tc pO2. This correlation do not exist in patients suffering from severe ischemia; it is likely that Xenon clearance actually measures total cutaneous blood flow, while tc pO2 constitutes an index of nutritional circulation. It is also possible that Xenon clearance is modified by changes in partition coefficient in ischemia areas.
在正常受试者和患有严重下肢动脉供血不足的患者足部，同时测量皮肤血流量（氙清除率）和经皮氧分压。当受试者坐着时，皮肤血流量会减少，正常受试者和大多数动脉供血不足的患者都是如此。然而，经皮氧分压在坐姿时会升高，这可能是因为局部加热消除了局部血管调节。在卧位时经皮氧分压非常低的患者中，坐姿时经皮氧分压的升高幅度更大。在正常受试者中，皮肤血流量与经皮氧分压之间存在正相关。在严重缺血的患者中不存在这种相关性；氙清除率可能实际上测量的是皮肤总血流量，而经皮氧分压则是营养循环的一个指标。也有可能是缺血区域分配系数的变化改变了氙清除率。
