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[13例患者腰交感神经切除术前、后使用铊201闪烁扫描术对下肢肌肉灌注的研究]

[Study of the muscular perfusion of the lower limbs using thallium 201 scintigraphy before and after lumbar sympathectomy in 13 patients].

作者信息

Serise J M, Basse-Cathalinat B, Medina M, Aguilar P, Le Héron D, Boissieras P

出版信息

J Mal Vasc. 1985;10 Suppl A:94-6.

PMID:4031690
Abstract

Scintigraphy with 201-Thallium is a useful method for exploring muscle circulation in lower limbs of patients with arteritis. Comparative values with time can be obtained by studying respective isotopic activity ratios of the thigh, calf and foot. Unilateral isolated lumbar sympathectomy was performed in 13 patients for arteriopathy of the lower limbs (7 claudications, 4 isolated trophic disorders, 1 thrash-foot and 1 juvenile arteriopathy). Investigations included clinical and arteriographic explorations and functional tests (Doppler, distal pressure, digital plethysmography and 201-Thallium muscle scintigraphy) before and after operation. Pathology of the sympathetic chain was determined in each case. Short-term (2 weeks) follow up examinations gave data showing absence of correlation between the operative procedure and scintigraphy results. Muscle perfusion was improved in only 3 cases: one presented paradoxical improvement contralateral to the sympathectomy, while no change from the pre-operative values was recorded in 9 patients. The findings raise questions concerning the reproducibility of the scintigraphic method, and also confirm the pathogenic hypothesis by which lumbar sympathectomy has only a limited effect on muscle circulation.

摘要

用铊-201进行闪烁扫描是探索动脉炎患者下肢肌肉循环的一种有用方法。通过研究大腿、小腿和足部各自的同位素活性比,可以获得随时间变化的对比值。对13例下肢动脉病患者(7例间歇性跛行、4例单纯营养障碍、1例鞭打足和1例青少年动脉病)实施了单侧孤立腰交感神经切除术。研究包括术前和术后的临床及动脉造影检查以及功能测试(多普勒、远端压力、数字体积描记法和铊-201肌肉闪烁扫描)。每例均确定了交感神经链的病理情况。短期(2周)随访检查的数据显示手术操作与闪烁扫描结果之间不存在相关性。仅3例患者的肌肉灌注得到改善:1例在交感神经切除对侧出现反常改善,而9例患者未记录到与术前值有变化。这些发现引发了关于闪烁扫描方法可重复性的问题,同时也证实了腰交感神经切除术对肌肉循环仅有有限作用的致病假说。

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