Shu Chinonso Paul, Tchinde Marius J, Sop Tsamayem Georter James, Ndonku Signang Alberic, Juma Paul Irungu
Pan-African Academy of Christian Surgeons, AIC Kijabe Hospital, Kijabe, Kenya.
Pan-African Academy of Christian Surgeons, Mbingo Baptist Hospital, Mbingo, Cameroon.
BMC Urol. 2025 May 2;25(1):112. doi: 10.1186/s12894-025-01795-7.
Prostate cancer (CaP) is the leading non-cutaneous cancer in men of African descent, with the higher mortality rates found in sub-Saharan Africa. Early diagnosis, staging, and management of prostate cancer could help curb its mortality rate in SSA. However, access to precise radiological imaging for staging purposes is limited in our setting. We sought to evaluate the correlation between total prostate specific antigen (tPSA) and histological grading of CaP in our resource-limited setting.
We conducted a retrospective review of records of patients treated for biopsy-proven CaP at the AICKH diagnosed between January 2018 and December 2022. We excluded patients who were already on any sort of treatment of bladder outlet obstruction and incomplete charts. We used Spearman correlation coefficients, and ANOVA to evaluate the relationship between tPSA and various grading parameters. A P-value less than 0.05 was considered significant.
We included 327 medical records. The mean tPSA was 112 ± 4.5ng/ml. The most common Gleason score and grade group were 8 (33.8%) and 4 (33.8%) respectively. Perineural involvement was present in 33% of our population. The tPSA had a positive correlation with Gleason score (rho = 0.253, p < 0.001), grade group (rho = 0.296, p < 0.001), perineural involvement (rho = 0.241, p = 0.001) and proportion of sample invasion (rho = 0.171, p = 0.005). A linear and homogenous variance existed in mean tPSA across increasing Gleason score (p < 0.001).
tPSA is a good predictor of the severity of CaP in resource-limited settings and can be used to inform management decisions.
前列腺癌（CaP）是非洲裔男性中最常见的非皮肤癌，在撒哈拉以南非洲地区的死亡率较高。前列腺癌的早期诊断、分期和管理有助于降低撒哈拉以南非洲地区的死亡率。然而，在我们的环境中，用于分期目的的精确放射学成像的获取有限。我们试图在我们资源有限的环境中评估总前列腺特异性抗原（tPSA）与CaP组织学分级之间的相关性。
我们对2018年1月至2022年12月在AICKH诊断为活检证实的CaP的患者记录进行了回顾性研究。我们排除了已经接受任何类型膀胱出口梗阻治疗和病历不完整的患者。我们使用Spearman相关系数和方差分析来评估tPSA与各种分级参数之间的关系。P值小于0.05被认为具有统计学意义。
我们纳入了327份病历。平均tPSA为112±4.5ng/ml。最常见的Gleason评分和分级组分别为8（33.8%）和4（33.8%）。33%的患者存在神经周围侵犯。tPSA与Gleason评分（rho = 0.253，p < 0.001）、分级组（rho = 0.296，p < 0.001）、神经周围侵犯（rho = 0.241，p = 0.001）和样本侵犯比例（rho = 0.171，p = 0.005）呈正相关。随着Gleason评分的增加，平均tPSA存在线性和均匀方差（p < 0.001）。
在资源有限的环境中，tPSA是CaP严重程度的良好预测指标，可用于指导管理决策。
