Department of Pathology, GGS Medical College -Faridkot, Punjab, India.
Department of Surgery, GGS Medical College -Faridkot, Punjab, India.
J Cancer Res Ther. 2023 Jul-Sep;19(5):1305-1310. doi: 10.4103/jcrt.jcrt_1719_21.
In India, prostate carcinoma is the fifth most common cause of carcinoma in men, and the fourth in cancer mortality. Incidence of prostate malignancy is increasing in India by one percent every year. Prostate carcinoma is graded using the Gleason scoring system. The Gleason score is very useful for predicting the prognosis of prostate carcinoma. The collaborative use of clinical features, combined with the size of the prostate, prostate-specific antigen levels, and histopathological features helps in making an accurate and early diagnosis of the patients.
This present prospective study included all histologically proven cases of prostate carcinoma in the Department of Pathology, Guru Gobind Singh Medical Hospital over a period of one year. A detailed histopathological examination of the H and E stained sections is carried out under light microscope including histological typing, Gleason scoring and grading. The Gleason grade was correlated with serum PSA levels.
Out of 80 cases, 28 (35%) were reported as Gleason grade group 3 with a Gleason score of 7 (4 + 3). 12 cases (15%) showed a Gleason grade group 2 with a Gleason score of 7 (3 + 4). Grade group 4 (Gleason score 8) and grade group 5 were observed in 22 cases (27.5%) and 18 cases (22.5%), respectively. Whereas, no case of Gleason grade group 1 with Gleason score of 6 (3 + 3) was seen.
Gleason's Group Grade 3 outnumbered all the group grades, contributing 35% (28 cases) of the total cases of prostatic adenocarcinoma. Serum PSA levels were raised (>10 ng/ml) in 100% of cases. Henceforth, it signifies the importance of serum PSA levels in prostate carcinoma. Lymphovascular invasion was associated with higher group grade of prostatic adenocarcinoma.
在印度，前列腺癌是男性中第五种最常见的癌症，也是癌症死亡的第四大原因。印度前列腺恶性肿瘤的发病率每年增长百分之一。前列腺癌的分级采用 Gleason 评分系统。Gleason 评分对于预测前列腺癌的预后非常有用。临床特征的协作使用，结合前列腺的大小、前列腺特异性抗原水平和组织病理学特征有助于对患者进行准确和早期诊断。
本前瞻性研究包括在 Guru Gobind Singh 医疗医院病理学系在一年内通过组织学证实的所有前列腺癌病例。在光学显微镜下对 H&E 染色切片进行详细的组织病理学检查，包括组织学类型、Gleason 评分和分级。Gleason 分级与血清 PSA 水平相关。
在 80 例中，28 例（35%）报告为 Gleason 分级组 3，Gleason 评分为 7（4+3）。12 例（15%）显示 Gleason 分级组 2，Gleason 评分为 7（3+4）。Gleason 分级组 4（Gleason 评分 8）和 Gleason 分级组 5 分别观察到 22 例（27.5%）和 18 例（22.5%）。而没有见到 Gleason 分级组 1，Gleason 评分为 6（3+3）。
Gleason 组 3 的数量超过了所有组的等级，占前列腺腺癌总病例的 35%（28 例）。100%的病例血清 PSA 水平升高（>10ng/ml）。因此，它标志着血清 PSA 水平在前列腺癌中的重要性。淋巴血管侵犯与前列腺腺癌的较高组分级相关。
