Brown Ashlyn, Lam Loc, Huh Billy, D'Souza Ryan S, Javed Saba
H. Ben Taub Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, TX, USA.
Department of Pain Medicine, Division of Anesthesiology, Critical Care Medicine, and Pain Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Curr Pain Headache Rep. 2025 May 3;29(1):82. doi: 10.1007/s11916-025-01389-w.
This narrative review explores the expanding applications of neuromodulation beyond pain management, focusing on its use in treating non-painful conditions such as heart failure, renal failure, spinal cord injuries, overactive bladder syndrome, and cognitive impairment in neurodegenerative diseases.
Neuromodulation techniques, including dorsal root ganglion stimulation, sacral neurostimulation, and deep brain stimulation, have shown promising results in various non-painful medical conditions: Heart and Renal Failure: Dorsal root ganglion stimulation induces diuresis in diuretic-resistant patients, offering a novel approach to managing fluid overload. Spinal Cord Injuries: Epidural spinal cord stimulation and brain-spine interfaces have demonstrated the potential to restore motor function, enhancing mobility and quality of life for paralyzed individuals. Overactive Bladder Syndrome: Sacral neurostimulation and tibial nerve stimulation have proven effective in improving urinary continence and reducing symptoms in patients unresponsive to conventional treatments. Cognitive Impairment in Neurodegenerative Diseases: Techniques such as deep brain stimulation and transcranial magnetic stimulation are being investigated for their ability to enhance cognitive and motor functions in conditions like Parkinson's and Alzheimer's disease. The review highlights the transformative potential of neuromodulation in non-painful conditions, demonstrating its ability to address complex medical issues beyond its traditional scope. Continued research and optimization of these techniques may lead to broader therapeutic applications and improved patient outcomes.
本叙述性综述探讨了神经调节在疼痛管理之外不断扩展的应用，重点关注其在治疗诸如心力衰竭、肾衰竭、脊髓损伤、膀胱过度活动症以及神经退行性疾病中的认知障碍等非疼痛性疾病方面的应用。
神经调节技术，包括背根神经节刺激、骶神经刺激和深部脑刺激，在各种非疼痛性医疗状况中已显示出有前景的结果：心力衰竭和肾衰竭：背根神经节刺激可诱导对利尿剂抵抗的患者产生利尿作用，为处理液体过载提供了一种新方法。脊髓损伤：硬膜外脊髓刺激和脑 - 脊髓接口已证明具有恢复运动功能的潜力，可增强瘫痪个体的活动能力和生活质量。膀胱过度活动症：骶神经刺激和胫神经刺激已被证明可有效改善对传统治疗无反应患者的尿失禁并减轻症状。神经退行性疾病中的认知障碍：诸如深部脑刺激和经颅磁刺激等技术正在被研究其在帕金森病和阿尔茨海默病等病症中增强认知和运动功能的能力。该综述强调了神经调节在非疼痛性疾病中的变革潜力，证明了其处理超出传统范围的复杂医疗问题的能力。对这些技术的持续研究和优化可能会带来更广泛的治疗应用并改善患者预后。
