Efficacy in Clinical Studies of a Skin Care Serum Formula Containing 7 Short and Long Saccharides and Bacterial Fractions to Repair and Strengthen the Skin Barrier From Aggressions in Intense Conditions.

BACKGROUND

A healthy skin barrier is essential to protect against the entry of harmful substances or the loss of internal fluids, especially water and electrolytes. Various aggressions are known to weaken the skin barrier.

AIMS

To evaluate single or multiple applications of a serum formula designed to mitigate skin barrier dysfunction and improve recovery after exposure to three different external aggressions (including one cumulative aggression under intense conditions).

PATIENTS AND METHODS

Five single-blind, controlled, intra-individual clinical studies in healthy subjects evaluated the effect of serum formula vs. untreated skin after aggression with harsh cleanser, emery paper abrasion, or tape stripping followed by exposure to 4°C or 40°C. Skin barrier function was assessed by transepidermal water loss (TEWL) and skin pH.

RESULTS

After harsh cleanser aggression, significant improvements in pH recovery and TEWL were observed after serum application, vs. untreated control, indicating significantly faster skin barrier recovery. Similarly, after tape stripping followed by intense cold or hot conditions, barrier function recovery was also significantly faster with an application of serum versus untreated control. In addition, serum-treated skin was more resistant against abrasion after serum treatment compared to the untreated control.

CONCLUSIONS

The serum formula, containing a unique combination of seven short and long saccharides and bacterial fractions, helped repair and strengthen the skin barrier to protect against abrasion. Taken together, these studies showed improved skin barrier recovery after exposure to different types of aggression (harsh cleanser or cumulative aggression by tape stripping followed by intense cold or hot conditions).