乙型肝炎表面抗原（HBsAg）携带者母亲的婴儿中，免疫球蛋白M型乙肝核心抗体在检测急性乙型肝炎病毒感染方面的不足

Inadequacy of immunoglobulin M hepatitis B core antibody in detecting acute hepatitis B virus infection in infants of HBsAg carrier mothers.

作者信息

Chen D S, Sung J L, Lai M Y, Sheu J C, Yang P M, Lee S C, Chen S H, Chang M H, Ko T M, Lee T Y

出版信息

J Med Virol. 1985 Aug;16(4):309-14. doi: 10.1002/jmv.1890160402.

Abstract

To study the usefulness of IgM hepatitis B core antibody (anti-HBc IgM) for detecting hepatitis B virus infections in infants of hepatitis B surface antigen (HBsAg) carrier mothers, serial serum samples from 86 infants of carrier mothers were tested for anti-HBc IgM with a highly specific enzyme immunoassay. Asymptomatic hepatitis B infection occurred frequently in infants under 12 mo of age. Anti-HBc IgM never became positive in 25 infants infected under 9 mo old. It was positive in only 1 of 6 infected at 9 mo and 4 of 13 infected at 12 mo of age. The IgM antibody lasted for less than 6 mo. Although the infection was delayed in 28 infants receiving hepatitis B immune globulin, the poor anti-HBc IgM response did not seem to be due to the immune prophylaxis. Our study clearly indicates the limitation of anti-HBc IgM for detecting acute hepatitis B infection in infants born to HBsAg carrier mothers.

摘要

为研究IgM型乙肝核心抗体（抗-HBc IgM）在检测乙肝表面抗原（HBsAg）携带者母亲所生婴儿乙肝病毒感染中的作用，采用高特异性酶免疫分析法对86名携带者母亲所生婴儿的系列血清样本进行了抗-HBc IgM检测。12个月龄以下婴儿中无症状乙肝感染较为常见。25名9个月龄以下感染的婴儿抗-HBc IgM从未呈阳性。9个月龄时感染的6名婴儿中仅1名呈阳性，12个月龄时感染的13名婴儿中有4名呈阳性。IgM抗体持续时间不到6个月。尽管28名接受乙肝免疫球蛋白的婴儿感染有所延迟，但抗-HBc IgM反应不佳似乎并非由于免疫预防。我们的研究清楚地表明了抗-HBc IgM在检测HBsAg携带者母亲所生婴儿急性乙肝感染中的局限性。