Panda S K, Bhan M K, Guha D K, Gupta A, Datta R, Zuckerman A J, Nayak N C
Department of Pathology, All-India Institute of Medical Sciences, New Delhi.
J Med Virol. 1988 Mar;24(3):343-9. doi: 10.1002/jmv.1890240311.
The significance of IgM and IgG class antibodies to hepatitis B virus (HBV) core component (anti-HBc) was investigated in a study of maternal-fetal HBV transmission. An IgM anti-HBc response was lacking in the majority (49/53) of HBV-infected infants. This antibody thus cannot be used as an indicator of transplacental infection. However, most infants who became HBsAg positive during the first 6 months of life acquire infection in the perinatal period rather than transplacentally. Passively transferred maternal IgG anti-HBc in the infant and additional IgM anti-HBc positively in the carrier mother have no modulating influence on HBV infection of infants born to HBV carrier women.
在一项关于母婴乙肝病毒传播的研究中，对乙型肝炎病毒（HBV）核心成分的IgM和IgG类抗体（抗-HBc）的意义进行了调查。大多数（49/53）感染HBV的婴儿缺乏IgM抗-HBc反应。因此，这种抗体不能用作经胎盘感染的指标。然而，大多数在出生后6个月内成为HBsAg阳性的婴儿是在围产期而非经胎盘获得感染。婴儿中被动转移的母体IgG抗-HBc以及携带者母亲中额外的IgM抗-HBc阳性对HBV携带者母亲所生婴儿的HBV感染没有调节作用。
