Li Ge, Li Chao, Liu Huimeng, Song Yunlong, Zhang Yuchen, Chen Ping, Zhang Hong, Wu Shaowei
Department of Occupational and Environmental Health, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi 710061, China; Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education, Xi'an 710061, China; Key Laboratory of Trace Elements and Endemic Diseases in Ministry of Health, Xi'an, Shaanxi 710061, China; Key Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, Xi'an, Shaanxi 710061, China; Shaanxi Provincial Center for Disease Control and Prevention, Xi'an, Shaanxi 710054, China.
Xijing Hospital, Air Force Medical University, Xi'an, Shaanxi 710032, China.
Ecotoxicol Environ Saf. 2025 Jun 1;297:118255. doi: 10.1016/j.ecoenv.2025.118255. Epub 2025 May 2.
To investigate the acute effects of short-term exposure to ambient air pollution on the risk of hospital admissions for osteoarthritis (OA) and its major subtypes.
Hospital admission data on OA and its major subtypes were sourced from two major urban medical insurance systems in China, covering the period from 2013 to 2017. A two-stage, time-stratified case-crossover design was used to investigate the acute effects of short-term exposure to ambient air pollutants on hospital admissions for OA across 278 Chinese cities with available hospital admission data over 50 cases. The conditional logistic regression model was utilized to assess city-specific associations, which were subsequently pooled by employing a random-effects model.
A total of 1,404,095 OA-related hospital admissions were included. At the main time windows, per interquartile range increases in PM (particulate matter with an aerodynamic diameter of ≤ 2.5 μm), PM (particulate matter with an aerodynamic diameter of ≤ 10 μm), NO (nitrogen dioxide), SO (sulfur dioxide), O (ozone), and CO (carbon monoxide) were associated with significant increases in OA-related admissions by 0.70 % (95 % CI: 0.12 %, 1.28 %), 1.08 % (95 % CI: 0.47 %, 1.69 %), 4.50 % (95 % CI: 3.36 %, 5.65 %), 2.75 % (95 % CI: 1.79 %, 3.72 %), 1.33 % (95 % CI: 0.57 %, 2.10 %) and 1.77 % (95 % CI: 0.76 %, 2.79 %), respectively. Short-term exposures to ambient air pollutants were also associated with increased hospital admissions for major OA subtypes, especially gonarthrosis. The attributable fractions of OA admissions ranged from 0.87 % for PM to 6.22 % for NO.
Short-term exposure to ambient air pollution is significantly associated with an increased risk and burden of OA admissions.
研究短期暴露于环境空气污染对骨关节炎（OA）及其主要亚型住院风险的急性影响。
OA及其主要亚型的住院数据来自中国两个主要城市医疗保险系统，涵盖2013年至2017年期间。采用两阶段、时间分层的病例交叉设计，研究短期暴露于环境空气污染物对278个有超过50例住院数据的中国城市OA住院的急性影响。使用条件逻辑回归模型评估特定城市的关联，随后采用随机效应模型进行汇总。
共纳入1,404,095例与OA相关的住院病例。在主要时间窗口，每四分位数间距增加的PM（空气动力学直径≤2.5μm的颗粒物）、PM（空气动力学直径≤10μm的颗粒物）、NO（二氧化氮）、SO（二氧化硫）、O（臭氧）和CO（一氧化碳）分别与OA相关住院病例显著增加0.70%（95%CI：0.12%，1.28%）、1.08%（95%CI：0.47%，1.69%）、4.50%（95%CI：3.36%，5.65%）、2.75%（95%CI：1.79%，3.72%）、1.33%（95%CI：0.57%，2.10%）和1.77%（95%CI：0.76%，2.79%）相关。短期暴露于环境空气污染物也与主要OA亚型的住院病例增加有关，尤其是膝关节炎。OA住院病例的归因分数范围从PM的0.87%到NO的6.22%。
短期暴露于环境空气污染与OA住院风险和负担增加显著相关。
