el-Yazigi A, Al-Mefty O
J Neurochem. 1985 Sep;45(3):815-8. doi: 10.1111/j.1471-4159.1985.tb04066.x.
CSF glutamine concentrations were studied in 12 patients with benign brain tumors (meningioma, craniopharyngioma, or osteofibroma), 12 patients with malignant brain tumors (astrocytoma, medulloblastoma, pinealoblastoma, or chondrosarcoma), 9 patients with noncerebral tumors, and a reference group of 24 patients. The mean +/- SD levels in the benign tumor group (424 +/- 124 microM) were significantly lower (p less than 0.0004) than those in the reference group (642 +/- 195 microM). There was no significant difference between the CSF glutamine concentrations in the malignant cerebral tumor group (643 +/- 210 microM) or noncerebral tumor group (599 +/- 127 microM) and those in the reference group. In patients with benign brain tumors there was indication of an inverse linear relationship between the logarithm of CSF glutamine concentration and tumor diameter.
对12例患有良性脑肿瘤（脑膜瘤、颅咽管瘤或骨纤维瘤）的患者、12例患有恶性脑肿瘤（星形细胞瘤、髓母细胞瘤、松果体母细胞瘤或软骨肉瘤）的患者、9例患有非脑肿瘤的患者以及24例作为参照组的患者的脑脊液谷氨酰胺浓度进行了研究。良性肿瘤组的平均±标准差水平（424±124微摩尔/升）显著低于参照组（642±195微摩尔/升）（p＜0.0004）。恶性脑肿瘤组（643±210微摩尔/升）或非脑肿瘤组（599±127微摩尔/升）的脑脊液谷氨酰胺浓度与参照组之间无显著差异。在患有良性脑肿瘤的患者中，脑脊液谷氨酰胺浓度的对数与肿瘤直径之间存在反向线性关系。
