Rivera Dalaena E, Poirier Kayla, Moore Samuel, Nicolle Ophélie, Morgan Emily, Longares Jonah Faye, Singh Anupama, Michaux Grégoire, Félix Marie-Anne, Luallen Robert J
Department of Biology, San Diego State University, San Diego, USA.
Univ Rennes, CNRS, IGDR (Institut de Génétique et Développement de Rennes) -UMR 6290, F-35000, Rennes, France.
NPJ Biofilms Microbiomes. 2025 May 3;11(1):70. doi: 10.1038/s41522-025-00696-9.
Bacterial adherence to the intestinal epithelium plays a role in niche establishment in the gut lumen. Through sampling natural populations of Caenorhabditis, we discovered several bacterial species that adhere to the intestinal epithelium via polar, intimate association, best described as attachment. These bacteria had varying effects on host fitness and physiology, with one species having negative effects, and the others exhibiting neutral effects. These bacteria can actively divide in the gut lumen, either replicating throughout the gut simultaneously or anteroposteriorly. In competition assays, animals pre-colonized with an attaching commensal bacteria reduced colonization by the pathogenic bacteria, but this effect was not seen when animals were colonized by both species simultaneously. Regardless of the colonization paradigm, populations exposed to both bacteria showed a near-identical mitigation of the pathogenic effects. Altogether, these strains illustrate the capacity of microbiome bacteria to attach, replicate, and establish a niche across the entire intestinal lumen.
细菌对肠道上皮的黏附在肠腔生态位的建立中发挥作用。通过对秀丽隐杆线虫自然种群进行抽样，我们发现了几种通过极性、紧密关联（最恰当地描述为附着）黏附于肠道上皮的细菌物种。这些细菌对宿主健康和生理机能有不同影响，其中一种有负面影响，其他的则表现为中性影响。这些细菌能在肠腔中活跃分裂，要么在整个肠道同时复制，要么从前向后复制。在竞争试验中，预先定殖有附着性共生细菌的动物减少了病原菌的定殖，但当动物同时被这两种细菌定殖时，这种效果并未出现。无论定殖模式如何，接触这两种细菌的群体都表现出对致病作用几乎相同的缓解。总之，这些菌株说明了微生物组细菌在整个肠腔附着、复制和建立生态位的能力。
