Szathmáry I, Selmeci L, Pósch E, Szobor A, Molnár J
J Neurol Neurosurg Psychiatry. 1985 Aug;48(8):757-61. doi: 10.1136/jnnp.48.8.757.
Lactate dehydrogenase (LDH) isoenzyme pattern and the percent of H-subunit content were determined in the thymus of 62 patients (55 with hyperplasia, 7 with tumours) after thymectomy. An increase in LDH1 relative activity indicates that in the thymus of patients with myasthenia gravis the ratio of mature differentiated thymocytes was higher than in the thymus of control subjects. LDH isoenzyme profiles of thymus tumours were similar to those described in other neoplasms, except that thymomas with apparent predominance of epithelial cells and with minimal lymphocytic reaction exhibited a marked elevation only in LDH2 relative activity, presumably associated with the specific (secretory) function of epithelial cells. The elevation of H-subunit content, a parameter characteristic of both thymic components (lymphoid and epithelial), correlated closely with a poor clinical condition in patients several years after surgery.
对62例患者（55例增生，7例肿瘤）胸腺切除术后的胸腺进行了乳酸脱氢酶（LDH）同工酶谱及H亚基含量百分比的测定。LDH1相对活性增加表明，重症肌无力患者胸腺中成熟分化胸腺细胞的比例高于对照组胸腺。胸腺肿瘤的LDH同工酶谱与其他肿瘤中描述的相似，只是上皮细胞明显占优势且淋巴细胞反应最小的胸腺瘤仅表现出LDH2相对活性显著升高，这可能与上皮细胞的特定（分泌）功能有关。H亚基含量升高是胸腺两种成分（淋巴细胞和上皮细胞）的特征参数，与术后数年患者的不良临床状况密切相关。
