Suleiman Adeiza Shuaibu, Bhattacharya Prosun, Islam Md Aminul
Department of Pharmaceutical Microbiology, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria, Kaduna, Nigeria; Department of Clinical pharmacy and pharmacy practice, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria.
Department of Sustainable Development, Environmental Science and Engineering, KTH Royal Institute of Technology, Teknikringen 10B, Stockholm SE 10044, Sweden.
J Infect Public Health. 2025 Jul;18(7):102802. doi: 10.1016/j.jiph.2025.102802. Epub 2025 Apr 30.
This study aimed to conduct first robust meta-meta-analysis on mecC and mecA-positive MRSA strains, determining their overall prevalence and temporal trends. It encompassed 14 meta-analyses, involving 322,269 samples from 553 index studies. MRSA strains exhibited mecA / mecC positivity ranging from 0.90 % to 69.98 %. Varied AMSTAR and QUOROM scores were observed. mecC-positive MRSA prevalence was 2.41 % (95 % CI: 0.72-7.78 %). Human mecA-positive MRSA had 21.77 % prevalence (95 % CI: 9.08-43.67 %), animal samples had 7.08 % prevalence (95 % CI: 3.93-12.42 %), and worldwide prevalence was 14.58 % (95 % CI: 6.61-29.14 %). Temporal trends reveal fluctuations, mecA prevalence spiked to 52.68 % in 2012 and decreased to 7.11 % in 2022. For mecC gene, the year 2015 marked a low incidence of 0.41 % (95 % CI: 0.05-3.54 %). Overall, mecA gene carriage surpassed mecC in MRSA strains, especially in humans.
本研究旨在对mecC和mecA阳性的耐甲氧西林金黄色葡萄球菌（MRSA）菌株进行首次稳健的元元分析，确定其总体流行率和时间趋势。该研究涵盖了14项元分析，涉及来自553项索引研究的322,269个样本。MRSA菌株的mecA / mecC阳性率在0.90%至69.98%之间。观察到不同的AMSTAR和QUOROM评分。mecC阳性MRSA的流行率为2.41%（95%CI：0.72 - 7.78%）。人类mecA阳性MRSA的流行率为21.77%（95%CI：9.08 - 43.67%），动物样本的流行率为7.08%（95%CI：3.93 - 12.42%），全球流行率为14.58%（95%CI：6.61 - 29.14%）。时间趋势显示存在波动，mecA流行率在2012年飙升至52.68%，在2022年降至7.11%。对于mecC基因，2015年发病率较低，为0.41%（95%CI：0.05 - 3.54%）。总体而言，MRSA菌株中mecA基因携带率超过mecC，尤其是在人类中。
