Liu Lu, Wang Linfang, Pang Kuo, Ma Shuangrao, Liu Yue, Zhao Jing, Liu Ruimin, Xia Xinghui
State Key Laboratory of Water Environment Simulation, School of Environment, Beijing Normal University, No. 19, Xinjiekouwai Street, Beijing, 100875, China.
Shanxi Key Laboratory of Sorghum Genetic and Germplasm Innovation, Sorghum Research Institute, Shanxi Agricultural University, Jinzhong, 030600, China.
Environ Pollut. 2025 Jun 15;375:126363. doi: 10.1016/j.envpol.2025.126363. Epub 2025 May 2.
Antibiotics present a more complex pollution profile in large rivers, particularly in suspended sediment-laden flows. This study quantified 25 antibiotics in surface water samples from the whole sediment-laden Yellow River. A new comprehensive prioritization index (CPI) was developed to identify priority risk control regions. The concentrations of the detected antibiotics ranged from 0.670 to 232 ng/L (mean: 9.62 ng/L), with the highest mean concentration observed for tetracyclines (TCs) at 20.2 ng/L. The most prominent antibiotic pollution was observed in the midstream region, with mean concentrations reaching 251 ng/L. Three SEMs were constructed for three antibiotic categories, with 75.6 % of the variation explained for SAs and CAs. Suspended particulate matter (SPM) significantly influences the environmental fate of antibiotics directly, negatively affecting TCs and QNs (λ = -0.302) but positively impacting SAs and CAs (λ = 0.475). Source apportionment precisely revealed that human sources in the midstream region and animal sources downstream contributed 80.75 % and 71.55 %, respectively. Although more than 85 % of the risk values were less than 0.1, the midstream region was identified as the priority control region (CPI >0.01). In particular, OFL, CTC, and ENO from human sources were the main contributors in the midstream region. This study elucidates antibiotic fate and risks in the whole sediment-laden Yellow River, providing a scientific basis for assessing pollution in other large rivers.
抗生素在大型河流中呈现出更为复杂的污染状况，尤其是在含沙量高的水流中。本研究对整个含沙黄河地表水样本中的25种抗生素进行了定量分析。开发了一种新的综合优先级指数（CPI）来确定优先风险控制区域。检测到的抗生素浓度范围为0.670至232纳克/升（平均值：9.62纳克/升），其中四环素类（TCs）的平均浓度最高，为20.2纳克/升。中游地区观察到最显著的抗生素污染，平均浓度达到251纳克/升。针对三类抗生素构建了三个结构方程模型（SEMs），其中磺胺类（SAs）和喹诺酮类（CAs）的变异解释率为75.6%。悬浮颗粒物（SPM）直接显著影响抗生素的环境归宿，对四环素类和喹诺酮类产生负面影响（λ = -0.302），但对磺胺类和喹诺酮类产生正面影响（λ = 0.475）。源解析精确显示，中游地区的人为源和下游地区的动物源分别贡献了80.75%和71.55%。尽管超过85%的风险值小于0.1，但中游地区被确定为优先控制区域（CPI >0.01）。特别是，来自人为源的氧氟沙星（OFL）、四环素（CTC）和恩诺沙星（ENO）是中游地区的主要贡献者。本研究阐明了整个含沙黄河中抗生素的归宿和风险，为评估其他大型河流的污染提供了科学依据。
