Nagamine Y, Suzuki J, Katakura R, Yoshimoto T, Matoba N, Takaya K
J Neurosurg. 1985 Oct;63(4):526-31. doi: 10.3171/jns.1985.63.4.0526.
Over the past 33 years the authors have treated 12 cases of skull metastasis from thyroid carcinoma, accounting for 2.5% of a total of 473 cases of thyroid cancer. A study of these 12 cases revealed the following characteristics. The mean age of the patients was 60.4 years and the predominant incidence was in the seventh decade of life. The incidence of skull metastasis from thyroid cancer was higher among women than among men. The primary sign was a soft hemispheric tumor resting on the skull. The tumors were rich in vascularity with osteolytic changes in the skull. The average period from diagnosis of the thyroid tumor until thyroidectomy was 14.3 years, and until discovery of the skull metastasis was 23.3 years. The clinical course was thus very long. The most frequent histopathological presentation was follicular adenocarcinoma. Such lesions were morphologically well differentiated, with little pleomorphism and atypism, but detailed examination showed infiltration into the vascular lumen or capsule. The mean survival time in these patients was 4.5 years from the time of diagnosis. The prognosis in this lesion was relatively poor, considering its long clinical course.
在过去33年里，作者共治疗了12例甲状腺癌颅骨转移患者，占473例甲状腺癌患者总数的2.5%。对这12例病例的研究揭示了以下特征。患者的平均年龄为60.4岁，主要发病年龄在70岁。甲状腺癌颅骨转移的发生率女性高于男性。主要体征是位于颅骨上的半球形软性肿瘤。肿瘤血管丰富，颅骨有溶骨性改变。从甲状腺肿瘤诊断到甲状腺切除术的平均时间为14.3年，到发现颅骨转移的平均时间为23.3年。因此临床病程很长。最常见的组织病理学表现是滤泡性腺癌。此类病变形态学上分化良好，几乎没有多形性和异型性，但详细检查显示有血管腔或包膜浸润。这些患者从诊断时起的平均生存时间为4.5年。考虑到其较长的临床病程，该病变的预后相对较差。
