Kong Laifa, Huang Qigang, Cheng Jianghua, Ding Yingwei, Wang Baodi
Department of Obstetrics and Gynecology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua Municipal Central Hospital, Jinhua, Zhejiang Province,China.
Department of Obstetrics and Gynecology, Jinhua Municipal Central Hospital, Jinhua, Zhejiang Province, China.
DNA Cell Biol. 2025 Jun;44(6):274-283. doi: 10.1089/dna.2025.0009. Epub 2025 May 5.
Sepsis is a serious systemic inflammatory condition triggered by a variety of pathogens, including bacteria and viruses, that can result in multiple organ failure and a life-threatening situation. Despite advances in medical care, the mortality rate for sepsis remains high even with aggressive treatment strategies such as antibiotic therapy, fluid resuscitation, and respiratory and circulatory support. Extracellular vesicles (EVs), as a novel nanoscale biocarrier, exhibit diverse biological functions including immune modulation and tissue regeneration, suggesting promising applications in the field. This article provides an overview of the diverse therapeutic effects of EVs derived from various sources in the management of sepsis. Furthermore, EVs not only possess intrinsic therapeutic properties, such as immune modulation, but also function as targeted delivery vehicles for a variety of drug molecules, leading to synergistic therapeutic outcomes. In conclusion, extracellular vesicle therapy is poised to emerge as a dynamic and innovative force driving advancements in sepsis treatment.
脓毒症是一种由多种病原体（包括细菌和病毒）引发的严重全身性炎症状态，可导致多器官功能衰竭并危及生命。尽管医疗护理有所进步，但即便采用抗生素治疗、液体复苏以及呼吸和循环支持等积极的治疗策略，脓毒症的死亡率仍然很高。细胞外囊泡（EVs）作为一种新型的纳米级生物载体，具有多种生物学功能，包括免疫调节和组织再生，显示出在该领域的应用前景。本文概述了源自各种来源的细胞外囊泡在脓毒症治疗中的多种治疗作用。此外，细胞外囊泡不仅具有诸如免疫调节等内在治疗特性，还可作为多种药物分子的靶向递送载体，从而产生协同治疗效果。总之，细胞外囊泡疗法有望成为推动脓毒症治疗进展的一股充满活力和创新性的力量。
