Zhenjiang Key Laboratory of High Technology Research on Exosomes Foundation and Transformation Application, Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, 301 Xuefu Road, Zhenjiang 212013, Jiangsu, China.
Cells. 2020 Mar 13;9(3):707. doi: 10.3390/cells9030707.
Extracellular vesicles (EVs), which are the main paracrine components of stem cells, mimic the regenerative capacity of these cells. Stem cell-derived EVs (SC-EVs) have been used for the treatment of various forms of tissue injury in preclinical trials through maintenance of their stemness, induction of regenerative phenotypes, apoptosis inhibition, and immune regulation. The efficiency of SC-EVs may be enhanced by selecting the appropriate EV-producing cells and cell phenotypes, optimizing cell culture conditions for the production of optimal EVs, and further engineering the EVs produced to transport therapeutic and targeting molecules.
细胞外囊泡（EVs）是干细胞的主要旁分泌成分，模拟了这些细胞的再生能力。在临床前试验中，通过维持干细胞特性、诱导再生表型、抑制细胞凋亡和调节免疫，干细胞来源的 EVs（SC-EVs）已被用于治疗各种形式的组织损伤。通过选择合适的产生 EV 的细胞和细胞表型、优化细胞培养条件以产生最佳 EV 以及进一步对产生的 EV 进行工程改造以运输治疗和靶向分子，可以提高 SC-EVs 的效率。
