一位未生育过的产妇在引产过程中获得性因子VIII缺乏。
Acquired factor VIII deficiency in a nulliparous patient undergoing induction of labor.
作者信息
Zayat Nawras, Huang Shirley, Filipovic Anthony, Bartley Lorie, Akkary Wissam
机构信息
Montefiore Medical Center, Jack D Weiler Hospital, Bronx, NY, USA.
State University of New York, Downstate Health Sciences University, Brooklyn, NY, USA.
出版信息
Case Rep Perinat Med. 2024 Mar 11;13(1):20230004. doi: 10.1515/crpm-2023-0004. eCollection 2024 Jan.
OBJECTIVES
To present a case of acquired factor VIII deficiency in the setting of labor and describe the challenges of its diagnosis and treatment.
CASE PRESENTATION
A 31-year-old woman was diagnosed with acquired factor VIII deficiency while undergoing induction of labor. Her labor and post operative course were complicated by epidural hematoma formation, prolonged postoperative surgical site bleeding, and subcutaneous hematoma. Management included blood products, human Factor VII, rituximab, and a steroid taper.
CONCLUSIONS
Acquired factor VIII deficiency can be challenging to diagnose and should be considered in the differential diagnosis in patients with prolonged bleeding accompanied by a prolonged activated partial thromboplastin time (aPTT).
目的
介绍一例分娩时获得性凝血因子VIII缺乏症病例，并描述其诊断和治疗的挑战。
病例介绍
一名31岁女性在引产过程中被诊断为获得性凝血因子VIII缺乏症。她的分娩和术后过程因硬膜外血肿形成、术后手术部位长时间出血和皮下血肿而复杂化。治疗措施包括血液制品、人凝血因子VII、利妥昔单抗和逐渐减量的类固醇。
结论
获得性凝血因子VIII缺乏症的诊断可能具有挑战性，对于伴有活化部分凝血活酶时间（aPTT）延长的长时间出血患者，应在鉴别诊断中予以考虑。
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