Antakanavar Gajanand M, Gaurav Vishal, Lalmuanpuii Gaby, Mallya Varuna, Dev Tanvi
Department of Dermatology, Maulana Azad Medical College, New Delhi, India.
Department of Pathology, Maulana Azad Medical College, New Delhi, India.
Indian J Otolaryngol Head Neck Surg. 2025 May;77(5):2216-2218. doi: 10.1007/s12070-025-05472-x. Epub 2025 Apr 11.
Kimura's disease (KD) is a rare, benign chronic inflammatory disorder of unknown etiology, predominantly affecting young Asian males. It typically presents with painless subcutaneous nodules in the head and neck region, often accompanied by lymphadenopathy, peripheral eosinophilia, and elevated serum IgE levels. We report a case of an 18-year-old male with multiple lobulated, non-tender swellings over the bilateral retroauricular regions and left cheek persisting for eight years. Histopathology from a peri-auricular lesion revealed hyperplastic lymphoid follicles with germinal centers, interfollicular eosinophilic infiltrates, and eosinophilic deposits. Laboratory tests showed marked eosinophilia and elevated IgE. Imaging demonstrated bilateral cervical lymphadenopathy and parotid gland involvement. A diagnosis of KD was made, and the patient responded well to oral corticosteroids. This case underscores the diagnostic challenges posed by KD, particularly in differentiating it from malignancies and angiolymphoid hyperplasia with eosinophilia. Recognition of this entity is crucial to avoid misdiagnosis and ensure appropriate treatment.
木村病（KD）是一种病因不明的罕见良性慢性炎症性疾病，主要影响年轻亚洲男性。其典型表现为头颈部无痛性皮下结节，常伴有淋巴结病、外周嗜酸性粒细胞增多和血清IgE水平升高。我们报告一例18岁男性，双侧耳后区域和左侧脸颊有多个分叶状、无压痛的肿胀，持续八年。耳周病变的组织病理学显示有生发中心的增生性淋巴滤泡、滤泡间嗜酸性粒细胞浸润和嗜酸性沉积物。实验室检查显示明显的嗜酸性粒细胞增多和IgE升高。影像学检查显示双侧颈部淋巴结病和腮腺受累。诊断为木村病，患者对口服糖皮质激素反应良好。该病例强调了木村病带来的诊断挑战，尤其是在将其与恶性肿瘤和嗜酸性粒细胞增多性血管淋巴样增生相鉴别时。认识这一疾病实体对于避免误诊和确保恰当治疗至关重要。
