Tauro David P, Kumar K Kiran, Shibani S, Hallikeri Kaveri
Professor and Consultant Surgeon, The Taulins Clinic, Center for Cranio Maxillofacial Plastic and Reconstructive Surgery, Bengaluru, Karnataka, India.
Reader, Department of Oral and Maxillofacial Pathology, Sibar Institute of Dental Sciences, Guntur, Andhra Pradesh, India.
J Oral Biol Craniofac Res. 2012 Jan-Apr;2(1):50-2. doi: 10.1016/S2212-4268(12)60012-8.
Kimura's disease (KD) is a rare chronic inflammatory disorder that involves the subcutaneous tissues and occurs predominantly in the head and neck region, frequently associated with regional lymphadenopathy or salivary gland involvement. Although, not an uncommon condition in the Asian countries, it is quite rare among the occidental civilization and in the western countries is more commonly diagnosed among Asian migrants. Kimura's disease is sometimes confused with angiolymphoid hyperplasia with eosinophilia, which occurs in the superficial skin of the head and neck region. The classical features of angiolymphoid hyperplasia with eosinophilia are characterized by a triad of painless subcutaneous masses in the head and neck region, blood and tissue eosinophilia, and markedly elevated immunoglobulin E (IgE) levels. Here, we report a case of a 33-year-old Indian male with KD who presented with unilateral nodular swelling in the right parotid region. The diagnosis was based on characteristic histopathologic findings in conjunction with peripheral eosinophilia and elevated serum IgE levels.
木村病(KD)是一种罕见的慢性炎症性疾病,累及皮下组织,主要发生在头颈部区域,常伴有局部淋巴结病或唾液腺受累。虽然在亚洲国家并非罕见疾病,但在西方文明中相当罕见,在西方国家,亚洲移民中更常被诊断出。木村病有时会与嗜酸性粒细胞增多性血管淋巴样增生相混淆,后者发生在头颈部区域的浅表皮肤。嗜酸性粒细胞增多性血管淋巴样增生的典型特征是头颈部区域出现无痛性皮下肿块、血液和组织嗜酸性粒细胞增多以及免疫球蛋白E(IgE)水平显著升高三联征。在此,我们报告一例33岁患有木村病的印度男性,其表现为右侧腮腺区单侧结节性肿胀。诊断基于特征性组织病理学发现以及外周嗜酸性粒细胞增多和血清IgE水平升高。