Ishida Natsuki, Onoue Shunya, Takebe Tomohiro, Takahashi Kenichi, Asai Yusuke, Tamura Satoshi, Matsuura Tomoharu, Yamade Mihoko, Iwaizumi Moriya, Hamaya Yasushi, Yamada Takanori, Osawa Satoshi, Sugimoto Ken
First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.
Department of Laboratory Medicine, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.
Gastroenterol Res Pract. 2025 Apr 25;2025:9984055. doi: 10.1155/grp/9984055. eCollection 2025.
Fecal calprotectin (FC) is a Crohn's disease (CD) biomarker, although the impact of disease duration on its accuracy remains unclear. This study was aimed at investigating the effects of CD disease duration on FC. In this prospective, single-center, cross-sectional study, we performed 113 endoscopies and biomarker measurements. Endoscopy results were assessed using the simple endoscopic score for Crohn's disease (SES-CD), with an SES-CD ≤ 2 defined as endoscopic remission (ER). Cohort 1 was divided into short-term and long-term disease groups. The associations of the SES-CD with C-reactive protein and FC were analyzed. The correlation coefficient of FC and the SES-CD was 0.670 for all cases. In Cohort 1, the correlation coefficient of FC and the SES-CD was > 0.670 for all subgroups of the short-term disease group (≤ 20 years). The correlation coefficient of FC and CD was < 0.670 for all subgroups of the long-term disease group (> 20 years). In Cohort 2, the correlation coefficients were > 0.670 (0.808) for the 0-4-year disease group and < 0.670 for the 5-14- and 15-40-year disease groups. The receiver-operating characteristic analysis performed to predict ER of all cases resulted in an area under the curve (AUC) of 0.8443, with large AUCs of 0.907, 0.816, and 0.770 observed for the 0-4-, 5-14-, and 15-40-year disease groups, respectively. FC was affected by CD duration, and it may be a useful biomarker of CD, especially in patients with a short disease duration.
粪便钙卫蛋白（FC）是克罗恩病（CD）的一种生物标志物，尽管病程对其准确性的影响尚不清楚。本研究旨在调查CD病程对FC的影响。在这项前瞻性、单中心横断面研究中，我们进行了113次内镜检查和生物标志物测量。使用克罗恩病简易内镜评分（SES-CD）评估内镜检查结果，SES-CD≤2定义为内镜缓解（ER）。队列1分为短期病程组和长期病程组。分析了SES-CD与C反应蛋白和FC之间的关联。所有病例中FC与SES-CD的相关系数为0.670。在队列1中，短期病程组（≤20年）的所有亚组中FC与SES-CD的相关系数均>0.670。长期病程组（>20年）的所有亚组中FC与CD的相关系数均<0.670。在队列2中，病程0 - 4年组的相关系数>0.670（0.808），病程5 - 14年组和15 - 40年组的相关系数<0.670。对所有病例预测ER进行的受试者工作特征分析得出曲线下面积（AUC）为0.8443，病程0 - 4年组、5 - 14年组和15 - 40年组分别观察到较大的AUC，分别为0.907、0.816和0.770。FC受CD病程影响，它可能是CD的一种有用生物标志物，尤其是在病程较短的患者中。
